Evidence map›Paper›PMID 42331880›Full record

ArticleScientific reports2026

Sustained intravitreal delivery of carnosic acid by RADA16 peptide hydrogel protects the retina in acute ocular hypertension.

Hao Hu, Yiyao Wang, Dadong Jia, Shi Luo, Yi Fan Deng, Ruwen Wang, Xiaoyu Liu, Xuelian Guo, Gang Wu, JingYi Sun and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hao HuThe Second People's Hospital of China, Three Gorges University, the Second People's Hospital of Yichang, Yichang, 443000, Hubei Province, China.
Yiyao WangThe Second People's Hospital of China, Three Gorges University, the Second People's Hospital of Yichang, Yichang, 443000, Hubei Province, China.
Dadong JiaThe Second People's Hospital of China, Three Gorges University, the Second People's Hospital of Yichang, Yichang, 443000, Hubei Province, China.
Shi LuoThe Second People's Hospital of China, Three Gorges University, the Second People's Hospital of Yichang, Yichang, 443000, Hubei Province, China.
Yi Fan DengBeijing Key Laboratory for Separation and Analysis in Biomedicine and Pharmaceuticals, School of Medical Technology, Beijing Institute of Technology, Beijing, 100081, China.
Ruwen WangThe Second People's Hospital of China, Three Gorges University, the Second People's Hospital of Yichang, Yichang, 443000, Hubei Province, China.
Xiaoyu LiuThe Second People's Hospital of China, Three Gorges University, the Second People's Hospital of Yichang, Yichang, 443000, Hubei Province, China.
Xuelian GuoThe Second People's Hospital of China, Three Gorges University, the Second People's Hospital of Yichang, Yichang, 443000, Hubei Province, China.
Gang WuCollege of Life Sciences, Wuchang University of Technology, Wuhan, 430223, China.
JingYi SunAnqing First People's Hospital affiliated to Anhui Medical University, Anqing, 246000, Anhui Province, China.
Liang LiangThe Second People's Hospital of China, Three Gorges University, the Second People's Hospital of Yichang, Yichang, 443000, Hubei Province, China. liangliang419519@163.com.

Funding

National Natural Science Foundation of China 81770920
6 · The paper itself

Abstract

This study investigates the use of RADA16 hydrogels for delivering carnosic acid (CA) in glaucoma treatment. Rheological tests at 0.5% (w/v), 1% (w/v), and 2% (w/v) concentrations showed significant elasticity, with Young's moduli of 30.18 Pa, 16.22 Pa, and 26.66 Pa, respectively. The 1% (w/v) concentration had the lowest stiffness, ideal for intravitreal injection. SEM revealed the hydrogel's porous microstructure. The RADA16-CA system provided sustained CA release over 72 h, peaking at 6 h. In vitro, high CA concentrations (≥ 256 μg/mL) were cytotoxic, but RADA16 and RADA16-CA enhanced cell proliferation. RADA16-CA demonstrated superior efficacy and biocompatibility. In an acute ocular hypertension model, RADA16-CA improved retinal health in rats by reducing retinal nerve fiber layer thickness, ROS-positive cells, and pro-inflammatory cytokines, while boosting cell survival and antioxidant activity.These findings highlight the potential of the RADA16-CA sustained-release system as an optimized approach for glaucoma treatment.

Indexed as

AbietanesHydrogelsOcular HypertensionPeptidesRetinaAnimalsCell SurvivalDelayed-Action PreparationsIntravitreal InjectionsRatsRheologyAbietanesDelayed-Action PreparationsHydrogelsPeptidessalvinAnti-inflammatory therapyCarnosic acidDrug-sustained-release systemGlaucomaInjectable RADA16 hydrogelRetinal ganglion cells

Identifiers

PMID42331880
PMCPMC13562530

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.