Evidence map›Paper›PMID 42331860›Full record

ArticleNature communications2026

Carbapenemase-producing carbapenem-resistant Enterobacterales in surgical intensive care unit patients in a tertiary hospital in India.

Lindsey R Hall, Emily E Benedict, Fabia Edathadathil, Jobin J Jacob, Devendhu Suresh, Yathu Krishna, Juby A Varghese, Jacaranda van Rheenen, Ige A George, Jennie H Kwon and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Lindsey R Hall *The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-6012-9899
Emily E Benedict *The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0003-3243-3874
Fabia Edathadathil *Amrita Institute of Medical Sciences and Research Center, Amrita Vishwa Vidyapeetham, Kochi, India.
Jobin J JacobChristian Medical College, Vellore, India.
Devendhu SureshAmrita Institute of Medical Sciences and Research Center, Amrita Vishwa Vidyapeetham, Kochi, India.
Yathu KrishnaAmrita Institute of Medical Sciences and Research Center, Amrita Vishwa Vidyapeetham, Kochi, India.
Juby A VargheseAmrita Institute of Medical Sciences and Research Center, Amrita Vishwa Vidyapeetham, Kochi, India.
Jacaranda van RheenenDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-5127-1298
Ige A GeorgeDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Jennie H KwonDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Margaret A OlsenDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Anil Kumar VasudevanAmrita Institute of Medical Sciences and Research Center, Amrita Vishwa Vidyapeetham, Kochi, India.
Emily E PetersenDivision of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Matthew WestercampDivision of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Surbhi LeekhaDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Gautam DantasThe Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0003-0455-8370
Balaji VeeraraghavanChristian Medical College, Vellore, India.ORCID http://orcid.org/0000-0002-8662-4257
Sudheer O VayothAmrita Institute of Medical Sciences and Research Center, Amrita Vishwa Vidyapeetham, Kochi, India.
Sanjeev K SinghAmrita Institute of Medical Sciences and Research Center, Amrita Vishwa Vidyapeetham, Faridabad, India. sanjeevksingh@fbd.amrita.edu.
David K WarrenDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. daviwarren@unmc.edu.ORCID http://orcid.org/0000-0001-8679-8241
Sumanth GandraDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. gandras@wustl.edu.ORCID http://orcid.org/0000-0003-1482-0854

Funding

INSTITUTIONAL TRAINING GRANT IN GENOMIC SCIENCET32HG000045 · NHGRI · WASHINGTON UNIVERSITY · PI MICHAEL R BRENT, Barak A Cohen · 1997 to 2026
$8.4M
NHGRI NIH HHS T32 HG000045U.S. Department of Health & Human Services | Centers for Disease Control and Prevention (CDC) Broad Agency Announcement, contract 75D30121C11969
6 · The paper itself

Abstract

Carbapenemase-producing carbapenem-resistant Enterobacterales (CP-CRE) transmission studies incorporating clinical and genomic data from hospitals in India are lacking. We prospectively enrolled surgical intensive care unit (SICU) patients in a tertiary-care hospital in India (July 29 to November 30, 2023) and collected peri-rectal swabs at SICU admission, SICU discharge, and hospital discharge, alongside SICU environmental sampling. CP-CRE isolates were whole-genome sequenced to investigate differences between community-acquired (CA), healthcare-associated (HCA), hospital-acquired (HA), and environmental isolates. Twenty-seven percent of participants were CP-CRE-colonized on SICU admission, with risk factors of previous hospitalization and exposure to ≥2 antimicrobials. Among 148 admission-negative patients, 115 had repeat PRS; 42 (36.5%) acquired CP-CRE (27 upon SICU discharge, 15 upon hospital discharge). bla

Indexed as

Bacterial Proteinsbeta-LactamasesCarbapenem-Resistant EnterobacteriaceaeEnterobacteriaceae InfectionsAnti-Bacterial AgentsCarbapenemsCross InfectionFemaleHumansIndiaIntensive Care UnitsMaleMicrobial Sensitivity TestsProspective StudiesTertiary Care CentersWhole Genome SequencingAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasescarbapenemaseCarbapenems

Identifiers

PMID42331860
PMCPMC13443886

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.