ArticleAnnals of hepato-biliary-pancreatic surgery2026
Bile duct segmental resection versus pancreaticoduodenectomy for middle-third extrahepatic cholangiocarcinoma: A propensity-matched, single-center retrospective analysis.
Article in Annals of hepato-biliary-pancreatic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Backgrounds/Aims: The optimal surgical approach for middle-third extrahepatic cholangiocarcinoma (MCC)-bile duct segmental resection (BDSR) or pancreaticoduodenectomy (PD)-remains controversial. This study aimed to compare the short- and long-term outcomes of BDSR and PD in patients with MCC. Methods: We retrospectively analyzed 570 patients who underwent curative-intent surgery for MCC between January 2010 and December 2022. Clinicopathological characteristics, surgical outcomes, and oncologic outcomes (progression-free survival [PFS] and overall survival [OS]) were compared after 1:3 propensity score matching. Results: Among 570 patients, 112 underwent BDSR and 458 PD. After propensity score matching, BDSR showed shorter operative time and hospital stay (both Conclusions: BDSR may offer perioperative advantages over PD, but is associated with inferior PFS, with no significant difference in OS. In patients who achieved R0 resection, the PFS and OS did not reach statistical significance. This suggests that BDSR should be considered only in highly selected patients in whom R0 resection is achievable.
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