Evidence map›Paper›PMID 42331415›Full record

ArticleJACC. Cardiovascular interventions2026

Failure Mechanisms in Off-Label Electrosurgery Devices for BASILICA, LAMPOON, and SESAME.

Jaime L Murray, Andre R Montes, Andrea E Jaimes, Robert J Lederman, D Korel Yildirim

Abstract read
In one paragraph

Article in JACC. Cardiovascular interventions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jaime L MurrayCardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Andre R MontesCardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Andrea E JaimesCardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Robert J LedermanCardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA. Electronic address: lederman@nih.gov.
D Korel YildirimCardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

Funding

Novel catheter treatment of valve diseaseZIAHL006040 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEDERMAN, ROBERT J · 2010 to 2025
$23.6M
MRI catheter design and fabricationZIAHL006041 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEDERMAN, ROBERT J · 2014 to 2025
$12.2M
Intramural NIH HHS ZIA HL006040Intramural NIH HHS ZIA HL006041
6 · The paper itself

Abstract

backgroundTranscatheter electrosurgery using off-label guidewire-catheter systems to traverse or lacerate tissue may fail unexpectedly or cause nontarget heating.

objectivesThe aim of this study was to identify mechanisms of energy loss and nontarget heating in off-label transcatheter electrosurgery systems.

methodsThe authors simulated electrosurgical traversal and flying-V laceration used in BASILICA (bioprosthetic or native aortic scallop intentional laceration to prevent iatrogenic coronary artery obstruction), LAMPOON (laceration of the anterior mitral leaflet to prevent outflow obstruction), and SESAME (septal scoring along the midline endocardium) in a 2-compartment benchtop model. Current distribution and regional heating were measured in metallic-braided and nonmetallic catheter assemblies.

resultsLonger, higher power energy applications caused substantial catheter shaft heating and diverted energy delivery away from traversal or laceration targets. This reflected coupling between the guidewire and metallic catheter components and was amplified by thermal damage to insulation. Shorter, lower power applications and nonmetallic catheters reduced these effects. In SESAME, the risk for dangerous intramyocardial heating was reduced by connecting the intracavitary limb of the flying-V to the electrosurgery generator, instead of the intramyocardial limb.

conclusionsMetallic braiding in commonly used microcatheters can divert energy away from electrosurgical targets to catheter shafts and cause clinically important nontarget heating. In this benchtop model, energy applications of ≤2 seconds largely avoided these failure modes. Operators should favor nonmetallic catheters when feasible, use the shortest effective energy applications, and in SESAME energize the intracavitary limb. Purpose-built electrosurgical devices may improve safety and reliability.

Indexed as

Cardiac CatheterizationCardiac CathetersElectrosurgerySesamumEquipment DesignEquipment FailureEquipment Failure AnalysisHot TemperatureHumansMaterials TestingModels, CardiovascularOcimum basilicumleaflet modificationradiofrequency wiresafetysteam poptranscatheter electrosurgery

Identifiers

PMID42331415
PMCPMC13309752

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.