SynthesisCornea2026
Association Between Keratoconus and Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.
Synthesis in Cornea, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate an association between inflammatory bowel disease and keratoconus. CLINICAL RELEVANCE: Keratoconus can be difficult to diagnose early, and because of its progressive nature, early treatment is beneficial to preserving vision. Understanding potential associations of systemic disease with keratoconus may aid the development of screening protocols and guide early management decisions.
methodsOur search of 5 key databases (PubMed, Ovid Medline, Scopus, Web of Science, and Embase) was conducted on October 16, 2024. The selected papers were categorized as patient studies or genetic association studies for analysis. The primary outcome was odds ratio. Meta-analysis and test of assumptions was conducted on patient studies. Bias assessments were conducted using Q-GENIE and ROBINS-E.
resultsOur search yielded 299 publication titles, of which 9 were included in our systematic review and 3 were incorporated into the meta-analysis. The aggregate odds ratio of patient-focused studies was 1.39 (95% confidence interval: 0.82-2.37). In the 4 studies investigating Crohn disease, there was no significant causal association (all P -values >0.05). All 5 genetic association studies demonstrated a genetic association between either inflammatory bowel disease (as a collective) and/or ulcerative colitis and keratoconus.
conclusionsThe literature demonstrated a genetic association between ulcerative colitis and keratoconus. This association has not been consistently replicated in patient-focused studies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.