ArticleCerebral cortex (New York, N.Y. : 1991)2026
Cortical functional connectivity in mouse models of early blindness: enucleation vs. anophthalmia.
Article in Cerebral cortex (New York, N.Y. : 1991), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Excitatory and inhibitory networks diverge following early blindness.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Early sensory deprivation drives large-scale reconfiguration of cortical networks, yet we still lack a clear understanding of the relative contributions of early visual experience and spontaneous prenatal retinal waves on the establishment of cortical networks. We compared two mouse models of early blindness, neonatal enucleation and congenital anophthalmia, across two genetic strains (C57Bl/6 J and ZRDBA) using mesoscopic calcium imaging of spontaneous activity and graph-theoretical analysis. Concomitantly, the functional network organization was redirected toward medial higher-order visual areas, the associative retrosplenial cortex, and somatosensory regions, while the primary and lateral visual cortices exhibited reduced influence and integration within the modular architecture. Notably, ZRDBA groups showed limited global changes to their cortical network. However, anophthalmic ZRDBA mice, lacking prenatal retinal waves, exhibited connectivity patterns more akin to enucleated C57Bl/6 J than to their enucleated littermates, suggesting a potential contribution of spontaneous prenatal retinal activity. These findings support a connectivity-constrained, experience-dependent model in which preexisting structural pathways guide diffuse, resilient reorganization following sensory loss.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.