Observational studyEuropean stroke journal2026
Patient-reported non-motor outcomes after endovascular thrombectomy and intravenous thrombolysis: an observational study.
Observational study in European stroke journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
introductionAdverse non-motor outcomes dominate the lived reality of post-stroke recovery, yet remain poorly understood after intravenous thrombolysis (IVT), endovascular thrombectomy (EVT) or both. We characterised the prevalence of outcomes in 13 non-motor domains, stratified by mRS scores, and identified baseline factors associated with adverse outcomes at 6 months follow-up.
methodsWe conducted a prospective observational sub-study within the Stroke Investigation Group in North and Central London (SIGNAL) registry to characterise non-motor outcomes after IVT, EVT or both. At 6 months, we assessed mRS alongside 13 patient-reported non-motor domains, including neuropsychiatric, fatigue, sleep, social participation, sensory, autonomic and cognitive outcomes. We used unadjusted analysis to estimate prevalence and adjusted multivariate logistic regression to investigate associated baseline factors.
resultsWe included 642/646 (99.3%) eligible surviving patients (median age 73 years; 43.5% female; median NIHSS = 5; mRS = 1) treated with IVT, EVT or both. At 6 months, the prevalence of adverse non-motor outcomes across 13 domains ranged from 18% to 56% across all treatment groups. Among patients with a favourable functional outcome (mRS 0-2, n = 409), fatigue (51.3%), sleep disturbance (47.6%) and mood problems (39.6%) were most prevalent. In those with an unfavourable outcome (mRS 3-5, n = 233), dependency in activities of daily living (51.0%), reduced social participation (44.3%) and bladder dysfunction (41.0%) were common. Stroke recurrence, female sex and baseline NIHSS > 5 were significantly associated with multiple adverse non-motor outcomes at 6 months.
conclusionDespite favourable mRS, a high proportion of patients treated with IVT and/or EVT report adverse non-motor outcomes. Systematic non-motor assessments alongside mRS are needed to accurately capture post-stroke symptom burden and guide person-centred life after stroke care.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.