Evidence map›Paper›PMID 42330309›Full record

ArticleClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

Usefulness of Clot Waveform Analysis-Activated Thromboplastin Time (APTT) for Diagnosing Thrombotic Diseases.

Hiyori Ikeda, Hideo Wada, Nobuo Arai, Masafumi Kimura, Jun Masuda, Nobuo Ito, Nozomi Ikeda, Yuhuko Ichikawa, Motoko Tanaka, Kaoru Azuma and 4 more

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Article in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hiyori IkedaDepartment of Central Laboratory, Mie Prefectural General Medical Center, Yokkaichi, Japan.
Hideo WadaDepartment of General and Laboratory Medicine, Mie Prefectural General Medical Center, Yokkaichi, Japan.ORCID 0000-0001-9021-8633
Nobuo AraiSysmex Corporation, Kobe, Hyogo, Japan.
Masafumi KimuraSysmex Corporation, Kobe, Hyogo, Japan.
Jun MasudaDepartment of Cardiology, Mie Prefectural General Medical Center, Yokkaichi, Japan.
Nobuo ItoDepartment of Neurology, Mie Prefectural General Medical Center, Yokkaichi, Mie, Japan.
Nozomi IkedaDepartment of Central Laboratory, Mie Prefectural General Medical Center, Yokkaichi, Japan.
Yuhuko IchikawaDepartment of Central Laboratory, Mie Prefectural General Medical Center, Yokkaichi, Japan.
Motoko TanakaDepartment of Central Laboratory, Mie Prefectural General Medical Center, Yokkaichi, Japan.
Kaoru AzumaDepartment of Central Laboratory, Mie Prefectural General Medical Center, Yokkaichi, Japan.
Minoru EzakiDepartment of Central Laboratory, Mie Prefectural General Medical Center, Yokkaichi, Japan.
Katsuya ShirakiDepartment of General and Laboratory Medicine, Mie Prefectural General Medical Center, Yokkaichi, Japan.
Motomu ShimaokaDepartment of Molecular Pathobiology and Cell Adhesion Biology, Mie University Graduate School of Medicine, Tsu, Japan.
Hideto ShimpoMie Prefectural General Medical Center, Mie, Yokkaichi, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ObjectiveClot waveform analysis (CWA)-activated partial thromboplastin time (APTT) has been used for the diagnosis of bleeding disorders. In addition to previous parameters such as Min 1, Min 2, and Max 2, we analyzed the area under the curve (AUC) of CWA (CWA-AUC) to examine its usefulness in the diagnosis of thrombosis.Materials and MethodsHypercoagulability in patients with acute myocardial infarction (AMI), acute cerebral infarction (ACI), chronic liver disease (CLD), and cancer and in healthy volunteers (HVs) was examined using CWA-APTT.ResultsMin 1 and Min 2 times were significantly shorter in patients with CLD, cancer, ACI, and AMI than in HVs. Min 1, Min 2, Max 2 and CWA-AUC were significantly higher in patients with cancer, ACI, and AMI than in HVs and patients with CLD and were significantly higher in individuals with thrombotic diseases (AMI and ACI) than in non-thrombotic individuals. ROC analyses for thrombosis vs. HVs or non-thrombotic individuals, Min 1, Min 2, Max 2, and CWA-AUC were useful for the diagnosis of thrombosis.In conclusionCWA-APTT was suggested to be potentially useful in diagnosing the risk of thrombosis, including AMI and ACI. Min1, Min2, and CWA-AUC are useful for diagnosing thrombosis, with CWA-AUC being the most effective.

Indexed as

ThrombosisAdultAgedFemaleHumansLiver DiseasesMaleMiddle AgedMyocardial InfarctionPartial Thromboplastin TimeAPTTAUCCWApeak heightthrombosis

Identifiers

PMID42330309
PMCPMC13305908

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.