Evidence map›Paper›PMID 42330289›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

SLC11A2 withholds divalent metals from

Emilia S Norberg, Trina L Westerman, Eddy Cruz, Summer D Bushman, John Salogiannis, Eric P Skaar, Johanna R Elfenbein, Leigh A Knodler

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Emilia S NorbergDepartment of Microbiology and Molecular Genetics, Robert Larner, M.D. College of Medicine, University of Vermont, Burlington, VT 05405.ORCID 0009-0007-7540-9301
Trina L WestermanDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706.ORCID 0000-0001-7417-1935
Eddy CruzDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706.
Summer D BushmanDepartment of Pathology, Microbiology, and Immunology, and Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN 37232.ORCID 0000-0002-5976-9805
John SalogiannisDepartment of Molecular Physiology and Biophysics, Robert Larner, M.D. College of Medicine, University of Vermont, Burlington, VT 05405.ORCID 0000-0002-1988-7284
Eric P SkaarDepartment of Pathology, Microbiology, and Immunology, and Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN 37232.ORCID 0000-0001-5094-8105
Johanna R ElfenbeinDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706.ORCID 0000-0002-4764-0713
Leigh A KnodlerDepartment of Microbiology and Molecular Genetics, Robert Larner, M.D. College of Medicine, University of Vermont, Burlington, VT 05405.ORCID 0000-0002-3028-2198

Funding

Increasing the Complexity of Microtubule-based transport: Cargo adaptors and Hitchhiking on Vesicles.R35GM150857 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI JOHN SALOGIANNIS · 2023 to 2026
$1.7M
A bacterial biosensor for intracellular metal availability in the gutR21AI166152 · NIAID · WASHINGTON STATE UNIVERSITY · PI KNODLER, LEIGH · 2022 to 2023
$449k
Differential regulation of three DMSO reductases during enteric salmonellosisF30AI169967 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI Eddy Cruz · 2023 to 2026
$188k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) F30AI169967HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R21AI166152NIAID NIH HHS F30 AI169967NIAID NIH HHS R21 AI166152NIGMS NIH HHS R35 GM150857
6 · The paper itself

Abstract

There is a constant tug-of-war for transition metals at the pathogen-host interface. Vertebrate hosts modulate the availability of metals to pathogens in a process known as nutritional immunity, but pathogens have evolved numerous countermeasures to this host defense strategy. The bioavailability of trace metals therefore shapes the outcome of disease. In mammals, epithelial cells lining the intestine are a major site of metal absorption. Intestinal epithelial cells (IECs) are also a target for invading enteric pathogens but the contribution of epithelium-intrinsic factors toward nutritional immunity is unclear. Using

Indexed as

Cation Transport ProteinsIntestinal MucosaMetalsSalmonella InfectionsSalmonella typhimuriumAnimalsCations, DivalentEpithelial CellsHost-Pathogen InteractionsIronManganeseMiceZincCations, DivalentCation Transport ProteinsIronManganeseMetalsZincbacteria-containing vacuoleenteric infectionsintestinal epithelial cellnutritional immunitySalmonella enterica

Identifiers

PMID42330289
PMCPMC13320715

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.