Pre-Amyloidosis Red-Flag Clinical Diagnoses in Light Chain (AL) Versus Age-Related Transthyretin (ATTRwt) Amyloidosis: Electronic Health Record-Based Descriptive Study.

Noel Estrada-Merly, Liliana E Pezzin, Rodney Sparapani, Anita D'Souza

Abstract read

In one paragraph

Article in JMIR medical informatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Noel Estrada-MerlyDepartment of Medicine, Division of Hematology/Oncology, Medical College of Wisconsin, 9200 W Wisconsin Ave, Office #C4204, Milwaukee, WI, 53226, United States, 1 414 805 0637.ORCID 0009-0008-4479-8882

Liliana E PezzinDivision of Epidemiology and Social Sciences, Institute of Health and Humanity, Medical College of Wisconsin, Milwaukee, WI, United States.ORCID 0000-0002-7598-1793

Rodney SparapaniDivision of Biostatistics, Data Science Institute, Medical College of Wisconsin, Milwaukee, WI, United States.ORCID 0000-0002-7780-6825

Anita D'SouzaDepartment of Medicine, Division of Hematology/Oncology, Medical College of Wisconsin, 9200 W Wisconsin Ave, Office #C4204, Milwaukee, WI, 53226, United States, 1 414 805 0637.ORCID 0000-0002-1092-5643

Funding

Early diagnosis of light chain amyloidosisR01HL166339 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Anita D'Souza · 2023 to 2026

$1.1M

NHLBI NIH HHS R01 HL166339

6 · The paper itself

Abstract

Unlabelled: This electronic health record-based study highlights distinct diagnostic patterns preceding a diagnosis of light chain (AL) and wild-type transthyretin (ATTRwt) amyloidosis; AL amyloidosis was more frequently preceded by renal, gastrointestinal, neurologic, and clonal plasma cell disorders, whereas ATTRwt amyloidosis was more commonly associated with cardiac manifestations and carpal tunnel syndrome.

Indexed as

Amyloid Neuropathies, FamilialElectronic Health RecordsImmunoglobulin Light-chain AmyloidosisHumansPrealbuminPrealbuminAL amyloidosisearly detectionEHRelectronic health recordselectronic health records algorithmsred-flag diagnosestransthyretinwild type ATTR

Identifiers

PMID42330197

DOI10.2196/85803

PMCPMC13286071

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.