ArticleJBRA assisted reproduction2026
Causal Relationship Between Gut Microbiota and Female Infertility: A Bidirectional Mendelian Randomization Analysis.
Article in JBRA assisted reproduction, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aims to investigate the causal relationship between gut microbiota and female infertility using a Mendelian randomization (MR) approach.
methodsA bidirectional MR analysis was conducted using genome-wide association study (GWAS) data from European populations. Genetic variants (SNPs) linked to 473 bacterial species were used as instrumental variables. Data on female infertility were obtained from the FinnGen study, while gut microbiota-related genetic data were sourced from the NHGRI-EBI GWAS Catalog. Several MR methods, including inverse-variance weighted (IVW) analysis, were employed to assess causal associations.
resultsSeven bacterial taxa, including Actinomycetales, Bifidobacterium, Bifidobacteriaceae, Actinobacteria, Prevotella sp002933775, GCA-900199385 sp900320755, and CAG-841 sp002479075, were found to have a protective effect against female infertility. Higher levels of these bacterial taxa were associated with a lower risk of infertility. No evidence of reverse causality was found, indicating a unidirectional relationship between gut microbiota and female infertility.
conclusionThis study supports the concept of a gut-reproductive axis by establishing causal relationships between specific bacterial species and female infertility, suggesting potential avenues for therapeutic interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.