Evidence map›Paper›PMID 42330097›Full record

ArticleCirculation2026

Tirzepatide Regulates Pacemaker Function by Modulating cAMP and Calcium Dynamics in Human Sinoatrial Node Cells.

Lu Ren, Nadjet Belbachir, Hao Zhang, Phung N Thai, Rihua Huang, Wenjuan Zhu, Xuekun Wu, Mengjie Xie, Jingshan Gao, Hyeon Yu Kim and 5 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lu RenStanford Cardiovascular Institute, Stanford University, CA (L.R., N.B., H.Z., R.H., W.Z., X.W., M.X., J.G., H.Y.K., T.L., J.S., J.C.W.).ORCID 0000-0002-9731-8562
Nadjet BelbachirStanford Cardiovascular Institute, Stanford University, CA (L.R., N.B., H.Z., R.H., W.Z., X.W., M.X., J.G., H.Y.K., T.L., J.S., J.C.W.).ORCID 0000-0002-6993-8326
Hao ZhangStanford Cardiovascular Institute, Stanford University, CA (L.R., N.B., H.Z., R.H., W.Z., X.W., M.X., J.G., H.Y.K., T.L., J.S., J.C.W.).ORCID 0000-0002-2646-0959
Phung N ThaiDepartment of Physiology, David Geffen School of Medicine at University of California, Los Angeles (H.Z., P.N.T.).ORCID 0000-0001-7344-150X
Rihua HuangStanford Cardiovascular Institute, Stanford University, CA (L.R., N.B., H.Z., R.H., W.Z., X.W., M.X., J.G., H.Y.K., T.L., J.S., J.C.W.).
Wenjuan ZhuStanford Cardiovascular Institute, Stanford University, CA (L.R., N.B., H.Z., R.H., W.Z., X.W., M.X., J.G., H.Y.K., T.L., J.S., J.C.W.).ORCID 0000-0003-2724-4825
Xuekun WuStanford Cardiovascular Institute, Stanford University, CA (L.R., N.B., H.Z., R.H., W.Z., X.W., M.X., J.G., H.Y.K., T.L., J.S., J.C.W.).
Mengjie XieStanford Cardiovascular Institute, Stanford University, CA (L.R., N.B., H.Z., R.H., W.Z., X.W., M.X., J.G., H.Y.K., T.L., J.S., J.C.W.).
Jingshan GaoStanford Cardiovascular Institute, Stanford University, CA (L.R., N.B., H.Z., R.H., W.Z., X.W., M.X., J.G., H.Y.K., T.L., J.S., J.C.W.).
Hyeon Yu KimStanford Cardiovascular Institute, Stanford University, CA (L.R., N.B., H.Z., R.H., W.Z., X.W., M.X., J.G., H.Y.K., T.L., J.S., J.C.W.).ORCID 0000-0002-1303-9954
Tianding LiuStanford Cardiovascular Institute, Stanford University, CA (L.R., N.B., H.Z., R.H., W.Z., X.W., M.X., J.G., H.Y.K., T.L., J.S., J.C.W.).
Junyi SunStanford Cardiovascular Institute, Stanford University, CA (L.R., N.B., H.Z., R.H., W.Z., X.W., M.X., J.G., H.Y.K., T.L., J.S., J.C.W.).
Zaniar GhazizadehDepartment of Medicine, Division of Cardiovascular Medicine, School of Medicine, Stanford University, CA (L.R., N.B., H.Z., R.H., W.Z., X.W., M.X., J.G., H.Y.K., T.L., J.S., Z.G., J.C.W.).ORCID 0000-0001-6747-4727
Manuel F NavedoDepartment of Pharmacology, University of California Davis School of Medicine (M.F.N.).ORCID 0000-0001-6864-6594
Joseph C WuStanford Cardiovascular Institute, Stanford University, CA (L.R., N.B., H.Z., R.H., W.Z., X.W., M.X., J.G., H.Y.K., T.L., J.S., J.C.W.).ORCID 0000-0002-6068-8041

Funding

Human iPSCs for Elucidating Intercellular Crosstalk Signaling in Dilated CardiomyopathyR01HL141371 · NHLBI · STANFORD UNIVERSITY · PI WONG, WING H., WU, JOSEPH C. · 2018 to 2025
$6.2M
Single Cell Sequencing of Human iPSC-CM Subtype Identity and FunctionR01HL145676 · NHLBI · STANFORD UNIVERSITY · PI MARK MERCOLA, Joseph C. Wu · 2019 to 2026
$5.1M
Human iPSC Model to Elucidate Metabolic Interplay in Diabetic CardimyopathyR01HL146690 · NHLBI · STANFORD UNIVERSITY · PI LIAO, RONGLIH, MERCOLA, MARK · 2019 to 2025
$5.1M
Advancing Personalized Cardiac Organoids - Converging In Vitro, In Chemico, and In Silico ModelsUM1TR006031 · NCATS · STANFORD UNIVERSITY · PI Afshin Beheshti, Sarah C Heilshorn · 2026 to 2026
$3.1M
cAMP signaling in vascular smooth muscle in health and diseaseR01HL161872 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NAVEDO, MANUEL F · 2022 to 2025
$2.6M
AI-driven Drug Discovery Targeting Cardiac Fibrosis in Aging HeartUG3AG097135 · NIA · STANFORD UNIVERSITY · PI SAYED, NAZISH, WU, JOSEPH C. · 2025 to 2025
$900k
NCATS NIH HHS UM1 TR006031NHLBI NIH HHS R01 HL141371NHLBI NIH HHS R01 HL145676NHLBI NIH HHS R01 HL146690NHLBI NIH HHS R01 HL161872NIA NIH HHS UG3 AG097135
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

calcium signalingcyclic AMPglucagon-like peptide-1 receptorinduced pluripotent stem cellsreceptors, gastric inhibitory polypeptidesinoatrial nodetirzepatide

Identifiers

PMID42330097
PMCPMC13288756

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.