Evidence map›Paper›PMID 42330053›Full record

ArticleCancer biology & therapy2026

CD69 blockade restores the bone marrow niche and delays leukemogenesis in a mouse model of

Yuchen Li, Xu Jiang, Yinfeng Gu, Xianfeng Zha, Jie Wu, Xiuli Wu, Chunli Qi, Shaohua Chen, Yangqiu Li, Zhenyi Jin and 2 more

Abstract read
In one paragraph

Article in Cancer biology & therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuchen LiInstitute of Hematology, Key Laboratory of Regenerative Medicine, Ministry of Education, Jinan University, Guangzhou, China.
Xu JiangInstitute of Hematology, Key Laboratory of Regenerative Medicine, Ministry of Education, Jinan University, Guangzhou, China.
Yinfeng GuInstitute of Hematology, Key Laboratory of Regenerative Medicine, Ministry of Education, Jinan University, Guangzhou, China.
Xianfeng ZhaDepartment of the Clinical Laboratory, First Affiliated Hospital, Jinan University, Guangzhou, China.
Jie WuDepartment of Hematology, First Affiliated Hospital of Jinan University, Guangzhou, China.
Xiuli WuInstitute of Hematology, Key Laboratory of Regenerative Medicine, Ministry of Education, Jinan University, Guangzhou, China.
Chunli QiInstitute of Laboratory Animals, Jinan University, Guangzhou, China.
Shaohua ChenInstitute of Hematology, Key Laboratory of Regenerative Medicine, Ministry of Education, Jinan University, Guangzhou, China.
Yangqiu LiInstitute of Hematology, Key Laboratory of Regenerative Medicine, Ministry of Education, Jinan University, Guangzhou, China.ORCID 0000-0002-0974-4036
Zhenyi JinInstitute of Hematology, Key Laboratory of Regenerative Medicine, Ministry of Education, Jinan University, Guangzhou, China.
Chengxiang XiaBeijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.
Ling XuInstitute of Hematology, Key Laboratory of Regenerative Medicine, Ministry of Education, Jinan University, Guangzhou, China.ORCID 0000-0002-7044-7663

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA subset of patients with chronic myelomonocytic leukemia (CMML) carries

methodsWe used a CMML mouse model driven by a single

results

conclusionOur findings suggest that CD69 may serve as a biomarker of BME immunological dysfunction in CMML.

Indexed as

Antigens, CDAntigens, Differentiation, T-LymphocyteBone MarrowLectins, C-TypeLeukemia, Myelomonocytic, ChronicMembrane ProteinsAnimalsAntibodies, MonoclonalCD69 AntigensDisease Models, AnimalHumansMiceMonomeric GTP-Binding ProteinsMutationT-Lymphocytes, RegulatoryTumor MicroenvironmentAntibodies, MonoclonalAntigens, CDAntigens, Differentiation, T-LymphocyteCD69 AntigensLectins, C-TypeMembrane ProteinsMonomeric GTP-Binding ProteinsNras protein, mouseanti-CD69 mAbCD69CMMLNras G12DTreg

Identifiers

PMID42330053
PMCPMC13290085

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.