ReviewFuture medicinal chemistry2026
Coumarin derivatives as antidiabetic agents: a comprehensive review on mechanistic insights, structure-activity relationships,
Review in Future medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
2 authors.
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Abstract
In recent years, coumarin has been structurally modified by combining it with heterocyclic or other active pharmacophores such as thiazolidinedione, hydrazone, triazole, cinnamic acid, aza group, oxadiazole, sulfonamide, and piperidinyl to influence molecular targets related to diabetes, such as aldose reductase (ALR2), α-glucosidase, α-amylase, dipeptidyl peptidase-4 (DPP-4), peroxisome proliferator-activated receptor alpha (PPAR-α), peroxisome proliferator-activated receptor gamma (PPAR-γ), and protein tyrosine phosphatase 1B (PTP1B). This review provides a structured overview of the structure-activity relationship (SAR) of coumarin-based derivatives, focusing on their substitution patterns and functional relationships, which affect potency, selectivity, and efficacy.
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