ArticleBreast cancer research and treatment2026
Efficacy and toxicity of neoadjuvant chemotherapy versus chemo-immunotherapy in triple-negative breast cancer patients with and without germline BRCA mutations.
Article in Breast cancer research and treatment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe addition of pembrolizumab (KN522) to neoadjuvant doxorubicin, cyclophosphamide (AC), carboplatin and paclitaxel (TC) has significantly improved survival, albeit with increased toxicity. This study aims to evaluate the effectiveness and toxicity of KN522 and to decouple the relative contributions of germline BRCA mutations (gBRCAmut) and pembrolizumab addition.
methodsA retrospective analysis of patients with stage II-III triple negative breast cancer, treated at a single tertiary medical center with either KN522 or ACTC.
resultsAmong 127 patients, four cohorts were evaluated: (1) KN522-gBRCAmut (n = 26), (2) KN522-BRCA wildtype (n = 53), (3) ACTC-gBRCAmut (n = 18), (4) ACTC-BRCA wildtype (n = 30). The KN522-gBRCAmut cohort achieved a remarkable pCR rate of 92.3%, compared to 60.4%, 55.6% and 36.7% in cohorts (2), (3) and (4) respectively. Multivariable analysis identified the KN522 protocol (OR 3.69, 95% CI 1.66-8.20; p = 0.001) and gBRCAmut status (OR 3.78, 95% CI 1.57-9.12; p = 0.003) as independent predictors of pCR. Achieving pCR was associated with improved event-free and overall survival (OS) in univariate analyses. In multivariable models, however, pCR remained a significant independent predictor of OS only (HR = 0.15, 95% CI: 0.03-0.72, p = 0.018). KN522 was associated with higher hospitalization rates (40.5% vs. 14.6%, p = 0.003) and more neutropenic fever (NF) events (32.9% vs. 2.1%, p < 0.001), likely due to lower G-CSF prophylaxis during the AC part of the KN522 protocol (21.5% vs. 68.8%, p < 0.001).
conclusionsIn this analysis, gBRCAmut carriers treated with KN522 achieved remarkably high pCR rates. The observed 40% hospitalizations, primarily due to NF, highlights the need for supportive care optimization, including G-CSF consideration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.