ArticleBiomechanics and modeling in mechanobiology2026
Stresses and fluid flow in lamina cribrosa through anisotropic poroelasticity.
Article in Biomechanics and modeling in mechanobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Changes in the nonlinear and viscoelastic mechanical properties of the rat lamina cribrosa under chronic high intraocular pressure.Frontiers in bioengineering and biotechnology · 2026Article
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Abstract
To investigate the mechanical correlations between intraocular pressure (IOP) variations and glaucoma, this study presents a linear transversely isotropic poroelastic model of the lamina cribrosa (LC) based on Reissner-Mindlin plate theory. A key feature of the proposed framework is its analytical tractability, which allows the governing poroelastic equations to be solved in closed form under appropriate mechanical and hydraulic boundary conditions. Within this setting, linearity is used to capture the reversible component of the tissue response, providing a baseline description of the coupled solid-fluid feedback on which more complex time-dependent phenomena, such as viscoelastic effects and remodelling, may build. The results indicate that both strain and stress measures (in the form of shear strain and deviatoric stress measures) peak in the peripheral region of the LC, which is currently suspected to be the initial site of glaucomatous damage. These quantities increase with IOP, suggesting a pressure-dependent mechanical insult to the retinal ganglion cell (RGC) axons. In parallel, the model predicts a monotonic reduction in fluid content as IOP rises, which may contribute to ischemic phenomena and disc haemorrhages. The influence of material anisotropy was also examined, revealing that isotropic assumptions tend to overestimate the fluid content while underestimating shear strain. Given the current experimental challenges in measuring blood flow within the LC, the proposed model provides a valuable framework for exploring the coupled mechanical-hemodynamic behavior of the tissue and for inverse estimation of its mechanical parameters, such as the stiffness of the opening for the central retinal vessels.
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