Evidence map›Paper›PMID 42329411›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

Acute and sub-acute toxicity assessment of tetrodotoxin in Sprague-Dawley rats following intramuscular injection.

Lijun Ren, Kexuan Zhou, Hao Xuan, Xinyi Zhao, Linchang Li, Chuanyang Sun, Jiqianzhu Zhang, Yijun Tian, Jinfeng Li, Xiaoyu Dai and 4 more

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lijun Ren *Department of Health Toxicology, Faculty of Naval Medicine, Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China.
Kexuan Zhou *School of Biological Sciences, University of Hong Kong, Hong Kong, 999077, China.
Hao Xuan *Department of Health Toxicology, Faculty of Naval Medicine, Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China.
Xinyi ZhaoDepartment of Health Toxicology, Faculty of Naval Medicine, Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China.
Linchang LiDepartment of Health Toxicology, Faculty of Naval Medicine, Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China.
Chuanyang SunDepartment of Health Toxicology, Faculty of Naval Medicine, Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China.
Jiqianzhu ZhangDepartment of Health Toxicology, Faculty of Naval Medicine, Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China.
Yijun TianDepartment of Health Toxicology, Faculty of Naval Medicine, Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China.
Jinfeng LiDepartment of Health Toxicology, Faculty of Naval Medicine, Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China.
Xiaoyu DaiDepartment of Health Toxicology, Faculty of Naval Medicine, Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China.
Jingjing MaoDepartment of Health Toxicology, Faculty of Naval Medicine, Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China.
Lang YanDepartment of Health Toxicology, Faculty of Naval Medicine, Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China. langyan@smmu.edu.cn.
Jikuai ChenDepartment of Health Toxicology, Faculty of Naval Medicine, Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China. chenjk@smmu.edu.cn.
Jiangbo ZhuDepartment of Health Toxicology, Faculty of Naval Medicine, Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China. jiangbozhu1@smmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tetrodotoxin (TTX) is a potent neurotoxin with therapeutic potential, particularly in the fields of analgesia, cancer pain treatment, and drug addiction therapy. However, its high toxicity and lack of antidotes limit its clinical application. This study evaluated the acute toxicity and sub-acute toxicity of TTX via intramuscular injection in Sprague-Dawley (SD) rats. The acute toxicity test employed the Bliss method to determine the median lethal dose (LD

Indexed as

TetrodotoxinAnimalsBody WeightDose-Response Relationship, DrugFemaleInjections, IntramuscularLethal Dose 50MaleRatsRats, Sprague-DawleyToxicity Tests, AcuteTetrodotoxinAcute toxicityIntramuscular injectionNOAELSprague–Dawley ratSub-acute toxicityTetrodotoxin

Identifiers

PMID42329411

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.