Observational studyRheumatology international2026
Elevated calculated serum osmolality during acute gout attacks is associated with pain severity and systemic ınflammation: a retrospective paired observational study.
Observational study in Rheumatology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute gout attacks are characterized by intense inflammatory activity and pain. This study aimed to evaluate changes in calculated serum osmolality during acute gout attacks compared with the inter-flare period and to investigate its associations with pain severity and systemic inflammatory markers. In this retrospective paired observational study, 79 patients with gout were evaluated during an acute attack and again in the inter-flare period. Calculated serum osmolality, inflammatory markers, pain visual analog scale (VAS) scores, and the number of involved joints were recorded. Paired comparisons, correlation analyses, linear mixed-effects models for paired acute/inter-flare comparisons, and multivariable linear regression analyses restricted to the acute attack period were performed. Calculated serum osmolality was significantly higher during acute gout attacks compared with the inter-flare period (296.6 ± 6.1 vs. 291.8 ± 5.1 mOsm/kg; p < 0.001), accompanied by significant increases in inflammatory markers and leukocyte indices. During acute attacks, calculated serum osmolality correlated with pain intensity, joint involvement, CRP, ESR, WBC count, and neutrophil count, but not with serum uric acid. In adjusted mixed-effects models, the acute attack period remained independently associated with higher calculated serum osmolality (β=+4.9 mOsm/kg; 95% CI 3.6-6.2; p < 0.001). In multivariable linear regression analyses restricted to the acute phase, higher calculated serum osmolality was associated with higher inflammatory marker levels. Elevated calculated serum osmolality during acute gout attacks was associated with higher inflammatory markers and greater pain severity. Further prospective studies are needed to clarify the clinical relevance and potential pathophysiological implications of this association.
Indexed as
Identifiers
42329410What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.