Evidence map›Paper›PMID 42329350›Full record

ArticleIndian pediatrics2026

Clinical and Antimicrobial Resistance Patterns of Salmonella enterica Serovar Paratyphi A Infections in Pediatric Population.

Surendra Bahadur Mathur, Dharmendra Kumar Singh, Naz Perween, Bhanu Kiran Bhakhri, Sumi Nandwani, Shipra Agrwal, Bimlesh Kumar

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Article in Indian pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Surendra Bahadur MathurDepartment of Pediatrics, Postgraduate Institute of Child Health, Sector - 30, Gautam Buddha Nagar, Noida, Uttar Pradesh, India. sbmathur05@gmail.com.ORCID http://orcid.org/0000-0003-4051-5036
Dharmendra Kumar SinghDepartment of Pediatrics, Postgraduate Institute of Child Health, Sector - 30, Gautam Buddha Nagar, Noida, Uttar Pradesh, India.
Naz PerweenDepartment of Microbiology, Postgraduate Institute of Child Health, Sector - 30, Gautam Buddha Nagar, Noida, Uttar Pradesh, India.
Bhanu Kiran BhakhriDepartment of Pediatrics, Postgraduate Institute of Child Health, Sector - 30, Gautam Buddha Nagar, Noida, Uttar Pradesh, India.
Sumi NandwaniDepartment of Microbiology, Postgraduate Institute of Child Health, Sector - 30, Gautam Buddha Nagar, Noida, Uttar Pradesh, India.
Shipra AgrwalDepartment of Pediatrics, Postgraduate Institute of Child Health, Sector - 30, Gautam Buddha Nagar, Noida, Uttar Pradesh, India.
Bimlesh KumarDepartment of Pediatrics, Postgraduate Institute of Child Health, Sector - 30, Gautam Buddha Nagar, Noida, Uttar Pradesh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to analyze the clinical profiles, antibiotic susceptibility patterns and biochemical characteristics of Salmonella enterica serovar Paratyphi A (SPA) infections in children.

methodsA retrospective observational study was conducted on hospitalized pediatric patients (< 18 years) admitted with blood culture-confirmed SPA infection between January 2022 and October 2024. Data on demographics, clinical features, treatment regimens, antibiotic susceptibility and outcomes were extracted from medical records. Statistical analyses were performed using SPSS, with P < 0.05 considered significant.

resultsForty-five cases were included, with a mean (SD) age of 7 (4.3) years. Fever was universal (100%), accompanied by vomiting (46.7%) and abdominal pain (44.4%). Hepatomegaly and splenomegaly were observed in 46.7 and 42.2% of the cases, respectively. Third-generation cephalosporins were the most commonly used antibiotics (95.6%), but resistance to ceftriaxone was significant (31%). Fluoroquinolone resistance was found in 85-100% of the isolates. Trimethoprim + sulfamethoxazole (100%) and chloramphenicol (90.6%) exhibited the highest susceptibilities. Extended-spectrum beta-lactamase (ESBL) and AmpC beta-lactamase production were detected in 35.6% and 26.7% of isolates, respectively.

conclusionEmerging antimicrobial resistance was observed among pediatric SPA isolates; however, short-term clinical outcomes were favorable, with good response to appropriately tailored antimicrobial therapy.

Indexed as

Antibiotic resistanceAntimicrobial stewardshipBeta-lactamCephalosporinEnteric feverMultidrug-resistant bacteria

Identifiers

PMID42329350

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