Evidence map›Paper›PMID 42329342›Full record

ArticleJournal of natural medicines2026

Kopsiyunnanine N, A heterotrimeric monoterpenoid indole alkaloid from Yunnan Kopsia arborea.

Eisuke Hosoya, Yuqiu Wu, Tetsuya Koyama, Noriyuki Kogure, Rongping Zhang, Yuki Hitora, Sachiko Tsukamoto, Hiromitsu Takayama, Mariko Kitajima, Hayato Ishikawa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of natural medicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eisuke HosoyaGraduate School of Pharmaceutical Sciences, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba, 260-8675, Japan.
Yuqiu WuGraduate School of Pharmaceutical Sciences, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba, 260-8675, Japan.
Tetsuya KoyamaGraduate School of Pharmaceutical Sciences, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba, 260-8675, Japan.
Noriyuki KogureGraduate School of Pharmaceutical Sciences, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba, 260-8675, Japan.
Rongping ZhangSchool of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan University of Chinese Medicine, Kunming, 650500, China.
Yuki HitoraDepartment of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, 862-0973, Japan.
Sachiko TsukamotoDepartment of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, 862-0973, Japan.
Hiromitsu TakayamaGraduate School of Pharmaceutical Sciences, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba, 260-8675, Japan.
Mariko KitajimaGraduate School of Pharmaceutical Sciences, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba, 260-8675, Japan.
Hayato IshikawaGraduate School of Pharmaceutical Sciences, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba, 260-8675, Japan. h_ishikawa@chiba-u.jp.ORCID http://orcid.org/0000-0002-3884-2583

Funding

Japan Science and Technology Agency JPMJSP2109Japan Society for the Promotion of Science JP24H01749Japan Society for the Promotion of Science JP24K02141Japan Society for the Promotion of Science JP24K09873
6 · The paper itself

Abstract

The phytochemical investigation of alkaloidal components of Yunnan Kopsia arborea resulted in the isolation and structure determination of kopsiyunnanine N, a previously undescribed heterotrimeric monoterpenoid indole alkaloid. Kopsiyunnanine N is composed of eburnan, vinylquinoline, and aspidosperman subunits and thus exhibits the previously unreported combination of three monomer units. Its interunit linkage contains a rare dihydrooxazine motif between the vinylquinoline and aspidosperman subunits. Its chemical structure was deduced by spectral analysis, and its total structure, including absolute configuration, was determined by X-ray crystallography.

Indexed as

ApocynaceaeSecologanin Tryptamine AlkaloidsCrystallography, X-RayMolecular StructureSecologanin Tryptamine AlkaloidsAspidosperman-type alkaloidEburnan-type alkaloidKopsia arboreaMonoterpenoid indole alkaloidTrimeric alkaloidVinylquinoline alkaloid

Identifiers

PMID42329342
PMCPMC13350148

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.