Evidence map›Paper›PMID 42329328›Full record

ReviewCurrent oncology reports2026

Sacituzumab Tirumotecan Across Gynecologic Malignancies: One Target, Multiple Diseases.

Amalia A Sofianidi, Evangelia Panagodimou, Emmanouil Kalampokas, Ioannis Georgakopoulos, Flora Zagouri

Abstract readReview
In one paragraph

Review in Current oncology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Amalia A SofianidiOncology Unit, Aretaieion University Hospital, National and Kapodistrian University of Athens School of Medicine, Vasilissis Sofias 76, Athens, 115 28, Greece. amaliasof@med.uoa.gr.ORCID 0009-0005-9882-9478
Evangelia PanagodimouSecond Department of Obstetrics and Gynecology, Aretaieion University Hospital, National and Kapodistrian University of Athens, Athens, 11527, Greece.
Emmanouil KalampokasSecond Department of Obstetrics and Gynecology, Aretaieion University Hospital, National and Kapodistrian University of Athens, Athens, 11527, Greece.
Ioannis GeorgakopoulosRadiation Oncology Unit, First Department of Radiology, Medical School, Aretaieion Hospital, National and Kapodistrian University of Athens, 11527, Athens, Greece.
Flora ZagouriOncology Unit, Aretaieion University Hospital, National and Kapodistrian University of Athens School of Medicine, Vasilissis Sofias 76, Athens, 115 28, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewSacizuzumab Tirumotecan is a novel antibody-drug conjugate targeting TROP2 glycoprotein, which is highly expressed across malignant cells. Sacizuzumab Tirumotecan has already demonstrated promising clinical activity in combating breast and lung cancer, and it is currently under evaluation for use against gynecologic malignancies. This review aims to highlight the therapeutic potential of Sacituzumab Govitecan in gynecologic malignancies and to summarize the most recent evidence supporting its clinical application. RECENT

findingsOngoing phase III trials of Sacituzumab Tirumotecan include cervical, ovarian, and endometrial cancers. Preliminary safety data of Sacituzumab Tirumotecan indicates a manageable toxicity profile, with the most commonly reported adverse events including hematologic toxicity, oral mucositis, and alopecia. Mature data from Phase III trials are anticipated to clarify the impact of Sacituzumab Tirumotecan on overall survival, progression-free survival, and objective response rates. Additionally, biomarker analyses may enhance patient selection strategies and refine prognostic assessment in gynecologic oncology.

Indexed as

Antibodies, Monoclonal, HumanizedAntineoplastic AgentsGenital Neoplasms, FemaleImmunoconjugatesCamptothecinCell Adhesion MoleculesFemaleHumansAntibodies, Monoclonal, HumanizedAntineoplastic AgentsCamptothecinCell Adhesion MoleculesImmunoconjugatessacituzumab govitecanAntibody drug conjugatesCervicalEndometrialMK-2870OvarianSacituzumab tirumotecanSac-TMT

Identifiers

PMID42329328
PMCPMC13287214

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.