Evidence map›Paper›PMID 42329289›Full record

ArticleInflammopharmacology2026

Amelioration of adjuvant-induced arthritis by carvacrol and Lactobacillus rhamnosus: role of pro-inflammatory cytokines and T cell-mediated inflammation.

Fatemeh Mohammadi, Merat Mahmoodi, Zahra Taghipour, Hamideh Bashiri, Jafar Ahmadi, Pouya Pashazadeh, Batoul Kavyani, Ali Jomehzadeh, Reza Nosratabadi

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Article in Inflammopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Fatemeh MohammadiAfzalipour Faculty of Medicine, Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran.
Merat MahmoodiDepartment of Medical Immunology, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Zahra TaghipourDepartment of Anatomical Sciences, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Hamideh BashiriDepartment of Physiology and Pharmacology, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Jafar AhmadiDepartment of Radiology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Pouya PashazadehAfzalipour Faculty of Medicine, Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran.
Batoul KavyaniDepartment of Medical Microbiology, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Ali JomehzadehDepartment of Medical Physics, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Reza NosratabadiDepartment of Medical Immunology, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran. nosratabadir@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is an ongoing, chronic, and systemic autoimmune disorder that affects connective tissues, one or more joints, cartilage, and bones. Recent researches have reported that carvacrol and probiotics can be used to ameliorate inflammatory disorders due to their anti-inflammatory and immune-modulatory properties. Therefore, this research was aimed to evaluate the effects of carvacrol and lactobacillus rhamnosus (L. rhamnosus) in the treatment of an animal model of rheumatoid arthritis, adjuvant-induced arthritis (AIA). Carvacrol and L. rhamnosus significantly diminished the severity levels of AIA, which was along with a reduction in the inflammatory cell populations in the synovial tissue. Additionally, carvacrol and L. rhamnosus significantly downregulated disease-related cytokines as well as an increase in the anti-inflammatory cytokines in compared to control groups. Furthermore, carvacrol and L. rhamnosus downregulated the differentiation of T-helper 1 (Th1) and Th17 cells while induced cell differentiation via regulating their key transcription factors. The current study demonstrated carvacrol and L. rhamnosus improved clinical and laboratory factors in the treatment of AIA.

Indexed as

Arthritis, ExperimentalCymenesCytokinesInflammationLacticaseibacillus rhamnosusProbioticsT-LymphocytesAnimalsAnti-Inflammatory AgentsArthritis, RheumatoidCell DifferentiationMaleMiceTh17 CellsTh1 CellsAnti-Inflammatory AgentscarvacrolCymenesCytokinesAdjuvant-induced arthritisCarvacrolLactobacillus rhamnosusRheumatoid arthritisT-helper cells

Identifiers

PMID42329289

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.