Evidence map›Paper›PMID 42329250›Full record

ReviewIntensive care medicine2026

PEEP and alveolar recruitment after 60 years of acute respiratory distress syndrome.

Domenico Luca Grieco, Remì Coudroy, Annemijn H Jonkman, Ling Liu, Francesca Collino, Luca S Menga, Tommaso Rosà, Glasiele Alcala, Katerina Vaporidi, Irene Telias and 5 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Intensive care medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Domenico Luca GriecoDepartment of Anesthesiology and Intensive Care Medicine, Catholic University of the Sacred Heart, Rome, Italy.
Remì CoudroyMédecine Intensive et Réanimation, CHU Poitiers, Poitiers, France.
Annemijn H JonkmanIntensive Care Volwassenen, Erasmus MC, Rotterdam, The Netherlands.
Ling LiuJiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, Jiangsu, China.
Francesca CollinoDepartment of Surgical Science, University of Turin, Turin, Italy.
Luca S MengaKeenan Research Center, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, Canada.
Tommaso RosàDepartment of Anesthesiology and Intensive Care Medicine, Catholic University of the Sacred Heart, Rome, Italy.
Glasiele AlcalaInterdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.
Katerina VaporidiDepartment of Intensive Care, University Hospital of Heraklion, University of Crete School of Medicine, Heraklion, Crete, Greece.
Irene TeliasInterdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.
Luigi CamporotaDivision of Anaesthetics, Pain Medicine and Intensive Care (APMIC), Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.
V Marco RanieriDepartment of Anesthesia, Critical Care and Emergency Medicine, Policlinico di Bari, Università degli Studi di Bari Aldo Moro, Bari, Italy.
Massimo AntonelliDepartment of Anesthesiology and Intensive Care Medicine, Catholic University of the Sacred Heart, Rome, Italy.
Laurent BrochardKeenan Research Center, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, Canada.
Salvatore M MaggioreUniversity Department of Medicine and Surgery, Libera Università del Mediterraneo-LUM University, Casamassima, Bari, Italy. maggiore@lum.it.ORCID http://orcid.org/0000-0002-1828-9143

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Positive end-expiratory pressure (PEEP) remains a cornerstone of acute respiratory distress syndrome management. However, randomized trials of PEEP strategies have yielded conflicting results, reflecting inter-individual heterogeneity. PEEP-induced alveolar recruitment enhances lung protection by redistributing tidal volume over a larger functional lung and reducing atelectrauma and bronchiolotrauma. Conversely, in poorly recruitable lungs, PEEP predominantly increases stress in already aerated regions, potentially exacerbating ventilator-induced lung injury and cardiovascular compromise. The net effect of PEEP reflects a patient-specific balance between recruitment and overdistension, shaped by hemodynamic tolerance. Clinical markers traditionally used for assessing PEEP response (gas exchange, compliance, and driving pressure), while informative at a population level, remain unreliable for clinical decision-making at the individual level. With the exception of specific subgroups (e.g., obesity), patients with PaO

Indexed as

Positive-Pressure RespirationPulmonary AlveoliRespiratory Distress SyndromeHumansTidal VolumeVentilator-Induced Lung InjuryAlveolar recruitmentARDSPEEPRespiratory mechanics

Identifiers

PMID42329250

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.