ReviewInflammatory bowel diseases2026
Anatomical, physiological, and luminal adaptations occurring in an ileoanal pouch: opportunities for improving outcomes.
Review in Inflammatory bowel diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundThe ileal pouch represents a unique adaptation of the ileum to serve the dual roles of nutrient absorption, fecal storage, and evacuation in a new luminal microenvironment. However, the adaptation process produces early histological inflammation and therefore clues in the development of pouchitis may lie in how the ileal pouch adapts.
aimsThis narrative review explored anatomical and luminal ileal pouch adaptations, with a goal of designing clinical strategies that can strengthen the resilience of the pouch mucosa.
methodsA comprehensive PubMed search was conducted, and findings were critically examined and summarized.
resultsPhysiologically, the ileum must acquire key adaptive features, such as water and electrolyte reabsorption and distention capabilities to support optimal pouch function. However, other adaptations, such as severe villous blunting and alterations in bile acid metabolism, may accelerate an inflammatory environment. The benefits of retaining ileal type characteristics such as aspects of mucosal architecture are unclear, whereas changes in permeability and epithelial nutrient utilization remain incompletely characterized. Significant knowledge gaps remain regarding the optimal pouch microenvironment, including how the microbiome and its metabolites contribute to pouchitis development, and current therapies to manage pouchitis have yielded limited success. Mechanistically informed studies that explore the dynamic interplay between pouch structure, microbiota, and dietary influences are needed to better design targeted therapies.
conclusionsThe ileal pouch undergoes a series of adaptations that are not fully understood. This review integrates current evidence to better understand these adaptations, highlights clinically relevant implications, and identifies key areas where further mechanistic investigation is needed.
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Registered trials
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