Evidence map›Paper›PMID 42328975›Full record

ArticlemBio2026

Mechanisms by which proline reductase of

Laura M Cersosimo, Madeline Graham, Auriane Monestier, Aidan Pavao, Jay N Worley, Johann Peltier, Bruno Dupuy, Lynn Bry

Abstract read
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Laura M CersosimoMassachusetts Host-Microbiome Center, Department Pathology, Brigham & Women's Hospital, Harvard Medical School. Boston, Boston, Massachusetts, USA.
Madeline GrahamMassachusetts Host-Microbiome Center, Department Pathology, Brigham & Women's Hospital, Harvard Medical School. Boston, Boston, Massachusetts, USA.
Auriane MonestierPathogenesis of Bacterial Anaerobes, Department of Microbiology, Institut Pasteur, Université Paris-Cité,UMR-CNRS, Paris, France.
Aidan PavaoMassachusetts Host-Microbiome Center, Department Pathology, Brigham & Women's Hospital, Harvard Medical School. Boston, Boston, Massachusetts, USA.
Jay N WorleyMassachusetts Host-Microbiome Center, Department Pathology, Brigham & Women's Hospital, Harvard Medical School. Boston, Boston, Massachusetts, USA.ORCID 0000-0002-5923-1159
Johann PeltierInstitute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, CEA, CNRS,, Gif-sur-Yvette, France.
Bruno DupuyPathogenesis of Bacterial Anaerobes, Department of Microbiology, Institut Pasteur, Université Paris-Cité,UMR-CNRS, Paris, France.ORCID 0000-0001-7176-8453
Lynn BryMassachusetts Host-Microbiome Center, Department Pathology, Brigham & Women's Hospital, Harvard Medical School. Boston, Boston, Massachusetts, USA.ORCID 0000-0002-8792-8527

Funding

STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JONATHAN C KAGAN · 1986 to 2026
$32.4M
Medical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7M
Commensal control of C. difficile virulenceR01AI153605 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI BRY, LYNN · 2021 to 2025
$3.4M
Harnessing commensal redox metabolism in infection preventionR01AI179807 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI LYNN BRY · 2024 to 2026
$2.5M
Molecular Epidemiology and Surveillance Optimization of Clostridioides difficile in Asymptomatic PatientsK01AI180357 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI CERSOSIMO, LAURA MARIE · 2024 to 2024
$136k
Institut PasteurLabEX IBEID (France)Massachusetts Life Sciences CenterNational Institute of Allergy and Infectious Diseases K01AI180357National Institute of Allergy and Infectious Diseases R01AI153605National Institute of Allergy and Infectious Diseases R01AI179807NIAID NIH HHS K01 AI180357NIAID NIH HHS R01 AI153605NIAID NIH HHS R01 AI179807NIDDK NIH HHS P30 DK034854NIDDK NIH HHS P30DK034854NIGMS NIH HHS T32 GM144273
6 · The paper itself

Abstract

IMPORTANCE:

Indexed as

Bacterial ProteinsClostridioides difficileClostridium InfectionsProlineAnimalsDisease Models, AnimalDisease ProgressionGastrointestinal MicrobiomeGene Expression ProfilingMiceBacterial ProteinsProlineClostridioides difficilecommensal bacteriaprdBproline metabolismStickland amino acids

Identifiers

PMID42328975
PMCPMC13463711

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.