Evidence map›Paper›PMID 42328776›Full record

ArticleAdvanced healthcare materials2026

Hydrogel Microtube Drug Carrier for Catheter-Based Intravascular Therapy.

Shota Sato, Hiroki Ohta, Naoki Takakura, Kentaro Kasa, Teppei Komatsu, Dai Kejia, Misato Yoshioka, Hirotaka James Okano, Hiroaki Onoe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shota SatoDepartment of Mechanical Engineering, Faculty of Science and Technology, Keio University, Yokohama, Kanagawa, Japan.
Hiroki OhtaDivision of Regenerative Medicine, Research Center for Medical Sciences, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan.
Naoki TakakuraDepartment of Mechanical Engineering, Faculty of Science and Technology, Keio University, Yokohama, Kanagawa, Japan.
Kentaro KasaDivision of Regenerative Medicine, Research Center for Medical Sciences, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan.
Teppei KomatsuDepartment of Neurology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan.ORCID https://orcid.org/0000-0002-9722-1656
Dai KejiaDivision of Regenerative Medicine, Research Center for Medical Sciences, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan.
Misato YoshiokaDivision of Regenerative Medicine, Research Center for Medical Sciences, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan.
Hirotaka James OkanoDivision of Regenerative Medicine, Research Center for Medical Sciences, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan.
Hiroaki OnoeDepartment of Mechanical Engineering, Faculty of Science and Technology, Keio University, Yokohama, Kanagawa, Japan.ORCID https://orcid.org/0000-0003-0048-1580

Funding

Japan Agency for Medical Research and DevelopmentTranslational Research program; Strategic Promotion for the practical application of Innovative Medical Technology JP26ym0126819
6 · The paper itself

Abstract

This paper proposes the hydrogel microtube carrier that can be retained within blood vessels without interrupting blood flow for the practical application of intravascular therapy. The stable three-dimensional network formed by the barium alginate gel enables the carrier to retain drugs within blood vessels. The utility of this hydrogel microtube carrier was confirmed through in vitro vascular mimic models and in vivo rat experiments. These experiments demonstrated that the hydrogel microtube carrier can be retained within blood vessels without obstructing blood flow and can deliver the drug model, Lipiodol, in the small renal artery. The hydrogel microtube carrier we propose represents a potential new platform advancing the practical application of intravascular drug delivery systems (DDS) and intravascular cell therapy.

Indexed as

CathetersDrug CarriersHydrogel, Polyethylene Glycol DimethacrylateHydrogelsAlginatesAnimalsDrug Delivery SystemsGlucuronic AcidHexuronic AcidsMaleRatsRats, Sprague-DawleyAlginatesDrug CarriersGlucuronic AcidHexuronic AcidsHydrogel, Polyethylene Glycol DimethacrylateHydrogelsDDS carrierhydrogelintravascular treatmentmicrofluidicsmicrotubes

Identifiers

PMID42328776
PMCPMC13507584

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.