ReviewEvolutionary applications2026
Integrative Advances in Equine Genomics From Reference Assemblies to Evolutionary History and Key Traits.
Review in Evolutionary applications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Horses are major domestic animals and cultural symbols that have accompanied humans for millennia. They underpin transport, agriculture, warfare and sport, and also provide a model for studying domestication, complex traits and adaptive evolution. Recent work in equine genomics has now generated a much richer picture of how these roles are grounded in the genome. This review brings together advances in several connected areas: the construction and refinement of reference assemblies; genomic reconstructions of origin, domestication and dispersal; global and regional patterns of genetic diversity; and the molecular basis of key traits such as athletic performance, coat colour, body size, environmental adaptation and inherited myopathies. The transition from EquCab1.0/2.0 to EquCab3.0 and a complete Y-chromosome sequence illustrates how long-read and Hi-C/T2T data improve genome completeness and the representation of complex regions. On this foundation, high-coverage resequencing of ancient and modern horses has clarified the geographical core of domestication in the Volga-Don region, the Bronze Age replacement of earlier domestic lineages and the long-term impact of human management on behaviour, conformation and mobility. Comparative analyses of mitochondrial DNA, Y-chromosomal haplotypes and autosomal runs of homozygosity further reveal a combination of diverse maternal lineages, highly constrained paternal lineages and breed-specific inbreeding histories. Against this background, studies of representative traits show how association signals, functional experiments and clinical evidence can be linked to practical tools for breeding and health management, for example through
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