Structural Modulation of TpPa‑1 Covalent Organic Framework in Flow Synthesis Guided by Green Chemistry Principles.

Yizhuo Xu, Nikita Rog, Catherine Mollart, Ganna Gryn'ova, Abbie Trewin, Cher Hon Lau

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Article in ACS engineering Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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6 authors.

Yizhuo XuSchool of Engineering, The University of Edinburgh, Edinburgh EH9 3FB, The United Kingdom of Great Britain and Northern Ireland.

Nikita RogSchool of Engineering, The University of Edinburgh, Edinburgh EH9 3FB, The United Kingdom of Great Britain and Northern Ireland.

Catherine MollartSchool of Chemistry, University of Birmingham, Birmingham B15 2TT, The United Kingdom of Great Britain and Northern Ireland.ORCID https://orcid.org/0000-0002-4263-0655

Ganna Gryn'ovaSchool of Chemistry, University of Birmingham, Birmingham B15 2TT, The United Kingdom of Great Britain and Northern Ireland.ORCID https://orcid.org/0000-0003-4229-939X

Abbie TrewinDepartment of Chemistry, Lancaster University, Lancaster LA1 4YB, The United Kingdom of Great Britain and Northern Ireland.ORCID https://orcid.org/0000-0002-1217-3254

Cher Hon LauSchool of Engineering, The University of Edinburgh, Edinburgh EH9 3FB, The United Kingdom of Great Britain and Northern Ireland.ORCID https://orcid.org/0000-0003-1368-1506

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here we present a solvent decision-making pathway for less hazardous and scalable synthesis of TpPa-1 covalent organic framework (COF) underpinned by environmental compatibility (CHEM21 framework), processability (Hansen solubility parameters), and thermodynamic suitability (free energy of solvation). Our analyses suggest that solvents with moderate solvation, such as 1,4-dioxane, propylene carbonate, and diacetin, hinder excessive reaction reversibility and promote crystallite growth. Balancing solvent greenness, compatibility, and thermodynamics, we find that diacetin is optimal for a continuous-flow synthesis. Compared with TpPa-1 COF synthesized in diacetin under batch conditions, the Brunauer-Emmett-Teller surface area of flow-derived TpPa-1 reached 418 m

Indexed as

Continuous-flow synthesisCovalent organic frameworks (COFs)Free energy of solvationGreen chemistryHansen solubility parametersSMD simulation

Identifiers

PMID42328503

DOI10.1021/acsengineeringau.5c00114

PMCPMC13281381

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LicenceCC BY

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