Evidence map›Paper›PMID 42328484›Full record

ArticleThe journal of allergy and clinical immunology. Global2026

Jinguo Chen, J Joanna Yu, Joseph Chiao, Yunkou Wu, Mark D Scarupa, Lili Wan, H Henry Li

Abstract read
In one paragraph

Article in The journal of allergy and clinical immunology. Global, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jinguo ChenVirant Diagnostics Laboratory, Wheaton, Md.
J Joanna YuVirant Diagnostics Laboratory, Wheaton, Md.
Joseph ChiaoVirant Diagnostics Laboratory, Wheaton, Md.
Yunkou WuVirant Diagnostics Laboratory, Wheaton, Md.
Mark D ScarupaAngioedema Centers of Reference and Excellence (ACARE) / Institute for Asthma and Allergy (IAA), Chevy Chase, Md.
Lili WanVirant Diagnostics Laboratory, Wheaton, Md.
H Henry LiVirant Diagnostics Laboratory, Wheaton, Md.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Bradykinin-mediated angioedema (AE-BK) remains diagnostically challenging particularly in patients with normal C1-inhibitor, where diagnosis primarily relies on clinical criteria. Routine laboratory tests can identify complement deficiency in hereditary angioedema due to C1-inhibitor deficiency (HAE-C1INH) but not directly assess kallikrein-kinin system dysregulation underlying these conditions. Objective: We sought to investigate potential associations between BK generation following Methods: Functional total BK generation Results: Elevated total BK following Conclusions: The measurement of

Indexed as

angioedema with normal C1INHbiomarkerbradykininBradykinin-mediated angioedemahereditary angioedemalong-term prophylaxisplasma kallikreinplasma kallikrein inhibitor

Identifiers

PMID42328484
PMCPMC13279001

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.