Evidence map›Paper›PMID 42328431›Full record

ArticleInternational journal of biological sciences2026

Role of WDR66 in Stemness, Therapy Resistance and Tumor microenvironment modulation in Head and Neck Cancer.

Laura Sanchez-Diaz, Asuncion Espinosa-Sánchez, Amancio Carnero

Abstract read
In one paragraph

Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Laura Sanchez-DiazInstituto de Biomedicina de Sevilla (IBIS)/HUVR/CSIC/Universidad de Sevilla, Sevilla, Spain.
Asuncion Espinosa-SánchezInstituto de Biomedicina de Sevilla (IBIS)/HUVR/CSIC/Universidad de Sevilla, Sevilla, Spain.
Amancio CarneroInstituto de Biomedicina de Sevilla (IBIS)/HUVR/CSIC/Universidad de Sevilla, Sevilla, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Head and neck cancer comprises a variety of malignant tumors affecting regions such as the oral cavity, pharynx, larynx, paranasal sinuses, nasal cavity and salivary glands. These tumors are highly heterogeneous, making it difficult to identify specific biomarkers and effective treatments, increasing mortality and recurrence rates. Databases analyzed to identify genes with altered expression in tumor tissue showed WDR66 able predict prognosis and survival, in HNSCC, but whose involvement in tumorigenesis is unknown. High WDR66 expression was associated with a worse prognosis, although its overexpression did not significantly alter basic tumor properties in cancer cells

Indexed as

Head and Neck NeoplasmsNeoplastic Stem CellsTumor MicroenvironmentAnimalsCell Line, TumorCell MovementDrug Resistance, NeoplasmGene Expression Regulation, NeoplasticHumansKruppel-Like Factor 4KLF4 protein, humanKruppel-Like Factor 4head and neck cancerimmune modulationstemnesstherapy resistanceWDR66

Identifiers

PMID42328431
PMCPMC13282750

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.