ArticleInternational journal of chronic obstructive pulmonary disease2026
Causal Relationship Between Methotrexate and Chronic Obstructive Pulmonary Disease: A Study Based on Network Toxicology and Mendelian Randomization.
Article in International journal of chronic obstructive pulmonary disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Methodological Concerns Regarding the Causal Relationship Between Methotrexate and COPD: The Missing Confounding by Indication [Response to Letter].International journal of chronic obstructive pulmonary disease · 2026Article
- Methodological Concerns Regarding the Causal Relationship Between Methotrexate and COPD: The Missing Confounding by Indication [Letter].International journal of chronic obstructive pulmonary disease · 2026Article
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Authors and funding
4 authors.
Funding
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Abstract
Introduction: Previous studies have shown that methotrexate (MTX) may have potential effects on chronic obstructive pulmonary disease (COPD), but the specific causal relationship remains unclear. Objective: This research intends to investigate whether a potential causal association exists between MTX usage and the risk of developing COPD. Methods: To systematically explore the potential association between MTX and the occurrence of COPD, this study adopted a multi-dimensional research strategy: on the one hand, the network toxicology method was used to predict the relevant action targets and metabolic pathways of MTX; on the other hand, the Mendelian randomization (MR) analysis method was applied to conduct research at the macro-epidemiological level. Results: Network toxicology analysis showed that MTX can affect the onset of COPD through multiple pathways and metabolic routes, and has strong binding energy with proteins encoded by Conclusion: This study suggests that there is a certain association between the use of MTX and the increased risk of COPD, providing new ideas for subsequent in - depth research.
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