ArticleResearch and practice in thrombosis and haemostasis2026
Real-world investigation of platelet apoptosis for mechanistic insights into severe immune thrombocytopenia and bleeding.
Article in Research and practice in thrombosis and haemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Given the low platelet counts in patients with immune thrombocytopenia (< 100 × 10 Key Clinical Question: Can an unconventional approach to platelet investigation provide important insights into a case of severe thrombocytopenia of unknown origin? Clinical Approach: The patient experienced repeated episodes of bleeding, including gastrointestinal bleeding, with platelet counts falling to critically low levels (< 10 × 10 Conclusion: Our approach, integrating a Platelet Mitochondrial Depolarization Assay with ELISA, demonstrates how detection of platelet apoptosis and platelet-targeting antibodies, can complement clinical investigation in bleeding disorders that involve severe platelet dysfunction and thrombocytopenia.
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