Evidence map›Paper›PMID 42328203›Full record

ArticlePatterns (New York, N.Y.)2026

Spacing effect improves generalization in biological and artificial systems.

Guanglong Sun, Ning Huang, Hongwei Yan, Jun Zhou, Qian Li, Bo Lei, Yi Zhong, Liyuan Wang

Abstract read
In one paragraph

Article in Patterns (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Guanglong SunSchool of Life Sciences, IDG/McGovern Institute for Brain Research, Tsinghua University, Beijing, China.
Ning HuangSchool of Life Sciences, IDG/McGovern Institute for Brain Research, Tsinghua University, Beijing, China.
Hongwei YanSchool of Life Sciences, IDG/McGovern Institute for Brain Research, Tsinghua University, Beijing, China.
Jun ZhouSchool of Life Sciences, IDG/McGovern Institute for Brain Research, Tsinghua University, Beijing, China.
Qian LiSchool of Medicine, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, Guangdong, China.
Bo LeiBeijing Academy of Artificial Intelligence, Beijing, China.
Yi ZhongSchool of Life Sciences, IDG/McGovern Institute for Brain Research, Tsinghua University, Beijing, China.
Liyuan WangDepartment of Psychological and Cognitive Sciences, Tsinghua University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Generalization is a fundamental criterion for evaluating learning effectiveness, a domain where biological intelligence excels yet artificial intelligence faces challenges. In biological learning and memory, the well-documented spacing effect shows that appropriately spaced intervals between learning trials significantly improve behavioral performance. While multiple theories have been proposed to explain its underlying mechanisms, one compelling hypothesis is that spaced training promotes integration of input and innate variations, thereby enhancing generalization to novel but related scenarios. Here, we examine this hypothesis by introducing a bio-inspired spacing effect into artificial neural networks, integrating input and innate variations across spaced intervals at neuronal, synaptic, and network levels. These spaced ensemble strategies yield significant performance gains across benchmark datasets and network architectures. Biological experiments on

Indexed as

bio-inspired learningensemble learninggeneralizationNeuroAIspacing effect

Identifiers

PMID42328203
PMCPMC13280723

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.