ArticleFrontiers in cellular and infection microbiology2026
Hl48 modulates argonaute 2 to enhance RNA interference in ticks.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Ticks are major vectors of human and animal pathogens, and the development of novel, species-specific control strategies is urgently needed. RNA interference (RNAi) holds promise as a targeted approach for tick control; however, its practical application has been limited by variable efficiency and an incomplete understanding of the underlying regulatory mechanisms in these arthropods. Methods: Using transcriptomic screening, molecular cloning, and functional genomics approaches, we identified and characterized Hl48, a previously uncharacterized ~48 kDa protein in Results: Hl48 expression was significantly upregulated in response to RNA virus infection or exogenous dsRNA stimulation, but not to protozoan infection, functionally linking it to the RNAi pathway. Silencing of Hl48 substantially impaired RNAi efficiency against multiple target genes, whereas its activation enhanced RNAi responsiveness both Conclusion: These findings establish Hl48 as a key positive regulator of the RNAi pathway in ticks, revealing a previously unrecognized layer of RNAi control in arthropods. This work provides a mechanistic foundation for the development of enhanced RNA-based strategies for tick-borne disease control.
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