Evidence map›Paper›PMID 42328122›Full record

ArticleInternational journal of medical sciences2026

Prognostic Role of Gut Microbiota and Clinical Parameters in Predicting Survival in Advanced Cholangiocarcinoma Patients Receiving Chemotherapy.

Thanika Ketpueak, Chanon Kunasol, Kanokphong Suparan, Nakarin Inmutto, Sunhawit Junrungsee, Nattayaporn Apaijai, Sasiwan Kerdphoo, Chanisa Thonusin, Chaiyut Charoentum, Thatthan Suksombooncharoen and 6 more

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Article in International journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

16 authors.

Thanika KetpueakDivision of Oncology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand, 50200.
Chanon KunasolNeurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand, 50200.
Kanokphong SuparanNeurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand, 50200.
Nakarin InmuttoDepartment of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand, 50200.
Sunhawit JunrungseeDepartment of Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand, 50200.
Nattayaporn ApaijaiCenter of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai, Thailand, 50200.
Sasiwan KerdphooNeurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand, 50200.
Chanisa ThonusinNeurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand, 50200.
Chaiyut CharoentumDivision of Oncology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand, 50200.
Thatthan SuksombooncharoenDivision of Oncology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand, 50200.
Sarawut KongkarnkaDepartment of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand, 50200.
Sirinart KumfuCenter of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai, Thailand, 50200.
Lakkhana SadaowMekong Health Science Research Institute, Khon Kaen University, Khon Kaen, Thailand, 40002.
Wanchai MaleewongMekong Health Science Research Institute, Khon Kaen University, Khon Kaen, Thailand, 40002.
Siriporn C ChattipakornNeurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand, 50200.
Nipon ChattipakornNeurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand, 50200.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Cholangiocarcinoma (CCA) is high prevalent in Asia. Emerging evidence indicates gut and tissue microbiota are involved in CCA carcinogenesis and progression. This study investigated the potential role of gut and tissue microbiota as prognostic biomarkers associated with treatment outcomes in advanced intrahepatic CCA (ICCA) patients. Methods: This prospective study comprised two cohorts: hepatocellular carcinoma (HCC) or ICCA patients undergoing surgery or biopsy, and unresectable ICCA patients treated with cisplatin and gemcitabine. Gut bacterial profiles were characterized from pre-treatment fecal samples using 16S rRNA and analyzed with clinical outcomes. Tissue bacterial profiles were determined by real-time qPCR. Results: In 30 ICCA patients receiving chemotherapy, gut microbiota differed based on chemotherapy response, PFS, overall survival, and Conclusion: Advanced ICCA patients with poor outcomes following chemotherapy exhibited the distinct pattern of gut microbiota, which might be used as potential prognostic biomarkers.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsBile Duct NeoplasmsCholangiocarcinomaGastrointestinal MicrobiomeAdultAgedAnimalsCarcinoma, HepatocellularCisplatinDeoxycytidineFemaleGemcitabineHumansLiver NeoplasmsMaleMiddle AgedCisplatinDeoxycytidineGemcitabinecholangiocarcinomagut microbiotahepatocellular carcinomaOpisthorchis viverrinisurvival

Identifiers

PMID42328122
PMCPMC13280742

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.