ArticleOphthalmology science2026
Preterm Optic Disc Morphology on Handheld OCT and 5-Year Visual Outcomes.
Article in Ophthalmology science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
Purpose: To determine whether neonatal optic disc morphology measured with handheld spectral-domain OCT (SD-OCT) predicts long-term visual acuity (VA) and refractive outcomes in premature infants. Design: Secondary retrospective analysis of an observational study. Subjects: Premature infants undergoing routine retinopathy of prematurity screening at a tertiary neonatal intensive care unit. Methods: Handheld SD-OCT was performed at approximately 36 weeks' postmenstrual age (PMA). A semiautomated algorithm quantified optic disc diameter, cup depth, and cup-to-disc ratio (CDR). Visual acuity and cycloplegic refraction were assessed at 9 months, 2 years, and 5 years. Main Outcome Measures: Visual acuity and spherical equivalent (SE) at 9 months, 2 years, and 5 years. Results: The study included 132 eyes from 66 premature infants. The mean disc diameter at 36 weeks' PMA was 1829 ± 270 μm, cup depth 517 ± 382 μm, and CDR 0.50 ± 0.24. The mean logarithm of the minimum angle of resolution VA was 0.69 ± 0.18 at 9 months, 0.65 ± 0.17 at 2 years, and 0.10 ± 0.15 at 5 years. The mean SE was 1.68 ± 1.54 diopters (D), 0.82 ± 1.87 D, and 0.58 ± 1.30 D, respectively. Optic disc metrics were not associated with VA or SEs at 9 months (n = 52 eyes) or 2 years (n = 39; Conclusions: Acknowledging a high lost to follow-up rate, neonatal optic disc morphology was not predictive of VA outcomes but was associated with refractive development, with deeper cups and larger CDRs linked to greater hyperopia at 5 years. These findings suggest novel biomarkers for refractive development in the preterm population that deserve further exploration. Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
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