ArticleFrontiers in insect science2026
Comparative metabolomics provides insights into the metabolic reprogramming of the predatory
Article in Frontiers in insect science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Methods: To investigate the metabolic mechanisms underlying cold adaptation, we conducted comparative metabolomic analyses combined with enzyme activity assays on Results: Despite a decline in survival during cold storage, the insects underwent extensive metabolic reprogramming in response to thermal stress. In total, 1,434 metabolites were identified, among which lipids and lipid-like molecules accounted for the largest proportion (43.72%). A total of 1,275 differentially expressed metabolites (DEMs) were detected, indicating pronounced metabolic reorganization and overall downregulation during prolonged cold exposure. KEGG pathway enrichment analysis identified eight major metabolic pathways and 46 key DEMs, suggesting that lipid and carbohydrate metabolism are central to cold tolerance. Mechanistically, the accumulation of long-chain polyunsaturated phospholipids and sphingomyelin is hypothesized to represent a crucial strategy for maintaining membrane fluidity, whereas the downregulation of ceramide may contribute to the suppression of apoptosis. In addition, elevated trehalase activity and the accumulation of compatible solutes likely function as essential cryoprotectants and antioxidants. Discussion: Collectively, these results provide a systematic characterization of the metabolic landscape of
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