Evidence map›Paper›PMID 42328000›Full record

ArticleAllergologie select2026

Update of the evidence- and consensus-based S3 guideline on atopic dermatitis: Systemic therapy with biologics or Janus kinase inhibitors and specific aspects of systemic therapy in pregnancy and lactation.

Thomas Werfel, Annice Heratizadeh, Matthias Augustin, Christine Bangert, Andrea Bauer, Tilo Biedermann, Richard Brans, Nadine Domröse, Uwe Gieler, Oliver Gießler-Fichtner and 30 more

Abstract read
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In one paragraph

Article in Allergologie select, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors.

Thomas WerfelDepartment of Dermatology and Allergy, Hannover Medical School, Hannover.
Annice HeratizadehDepartment of Dermatology and Allergy, Hannover Medical School, Hannover.
Matthias AugustinCompetence Center for Health Services Research in Dermatology (CVderm), Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Christine BangertDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
Andrea BauerDepartment of Dermatology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden.
Tilo BiedermannTUM University Hospital, Department of Dermatology and Allergy, Munich.
Richard BransInstitute for Interdisciplinary Dermatological Prevention and Rehabilitation (iDerm) at the Osnabrück University, Osnabrück.
Nadine DomröseDepartment of Dermatology and Allergy, Hannover Medical School, Hannover.
Uwe GielerDepartment of Psychosomatic Medicine and Psychotherapy, University Hospital Gießen, Gießen.
Oliver Gießler-FichtnerGaißach Specialist Clinic of DRV Bayern Süd, Gaißach.
Eckard HamelmannChildren's Center, Evangelical Hospital Bethel, University Hospital OWL, University of Bielefeld, Bielefeld.
Selina HampeGerman Allergy and Asthma Association (DAAB), Mönchengladbach.
Ruben HeuerDepartment of Dermatology, Venereology and Allergology, Division of Evidence Based Medicine in Dermatology (dEBM), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin.
Julia KahleGerman Allergy and Asthma Association (DAAB), Mönchengladbach.
Maria KinbergerDepartment of Dermatology, Venereology and Allergology, Division of Evidence Based Medicine in Dermatology (dEBM), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin.
Markus KochAlpenklinik Santa Maria, Bad Hindelang.
Meike KöhlerSection for Integrated Pediatric Dermatology (iKinD), Munich Center for Children with Medical and Developmental Complexity, LMU University Hospital, Munich, Germany.
Franz LegatDepartment of Dermatology and Venereology, Medical University of Graz, Graz, Austria.
Katja NematPractice for pediatric pneumology and allergology, Children's Center Dresden-Friedrichstadt (Kid).
Irena NeustädterHospital Hallerwiese, Cnopfsche Kinderklinik, Nuremberg.
Eva M J PetersPsychoneuroimmunology Laboratory, Department of Psychosomatic Medicine and Psychotherapy, Justus-Liebig University Gießen, Gießen, Germany.
Susanne Radonjic-HoesliDepartment of Dermatology, Inselspital Bern, Bern, Switzerland.
Imke ReesePrivate Practice for Dietary Advice and Nutrition Therapy with Special Interest in Adverse Reactions to Food, Munich, Germany.
Peter Schmid-GrendelmeierAllergy Unit, Department of Dermatology, University Hospital Zurich and Christine Kuehne Center for Allergy Research and Education CK-CARE Davos, Switzerland.
Uta-Katharina Schmidt-GöhrichCarus Family Practice at Dresden University Hospital.
Jochen SchmittCenter for Evidence-Based Healthcare (ZEGV), University Hospital Dresden and Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden.
Christina SchnoppTUM University Hospital, Department of Dermatology and Allergy, Munich.
Thomas SchwennesenGerman Eczema Association (DNB), Hamburg.
Dagmar SimonDepartment of Dermatology, Inselspital Bern, Bern, Switzerland.
Kristina StamosDepartment of Pediatrics, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden.
Christian TermeerDermatology Practice at Löwenmarkt, Stuttgart-Weilimdorf.
Regina TreudlerInstitute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin.
Ralph von KiedrowskiSelters Dermatology Practice, Selters.
Iris WagnerGerman Eczema Association (DNB), Hamburg.
Anja Waßmann-OttoMensing Derma MVZ, Hamburg.
Gesine WeckmannWeckmann Institute of Medical and Healthcare Education, Rostock.
Ricardo Niklas WernerDepartment of Dermatology, Venereology and Allergology, Division of Evidence Based Medicine in Dermatology (dEBM), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin.
Andreas WollenbergDepartment of Dermatology and Allergology, University Hospital Augsburg, Augsburg.
Margitta WormDepartment of Dermatology, Venereology, and Allergology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, and.
Hagen OttSection for Integrated Pediatric Dermatology (iKinD), Munich Center for Children with Medical and Developmental Complexity, LMU University Hospital, Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This guideline is a partial update of the S3 guideline on atopic dermatitis (AWMF register no. 013-027) published in 2023. The chapters on systemic therapy with biologics and Janus kinase inhibitors as well as the chapter on pregnancy, breastfeeding and family planning in the context of systemic therapies for atopic dermatitis have been updated. This was prompted by new approvals (lebrikizumab, nemolizumab), approval extensions (abrocitinib from 12 years of age, baricitinib from 2 years of age) and new evidence on the use of biologics before and during pregnancy. In addition, a new chapter on treatment goals, treatment expectations and criteria for treatment adjustment ("treat-to-target") in systemic therapies has been added to the guideline. This article only presents the updated and newly added chapters. The complete guideline is available on the AWMF website.

Identifiers

PMID42328000
PMCPMC13276969

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.