Evidence map›Paper›PMID 42327978›Full record

ArticleGenes & diseases2026

8-Chloroadenosine suppresses hepatocellular carcinoma progression via ADAR1/PPARγ axis-mediated lipid metabolism.

Jing Liu, Yongle Zhao, Xue Gong, Lin Yuan, Shengyong Yang, Wenwen Jian, Han Yan, Honglin Chen, Zhicheng Yang, Yiheng Sun and 4 more

Abstract read
In one paragraph

Article in Genes & diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jing LiuDepartment of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Yongle ZhaoDepartment of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Xue GongDepartment of Pathogen Biology, College of Basic Medical Science, Chongqing Medical University, Chongqing 400016, China.
Lin YuanMedical Laboratory Department, Xi'an No. 1 Hospital, Xi'an, Shaanxi 710000, China.
Shengyong YangDepartment of Biochemistry and Molecular Biology, Molecular Medicine and Cancer Research Center, College of Basic Medicine, Chongqing Medical University, Chongqing 400016, China.
Wenwen JianDepartment of Pathogen Biology, College of Basic Medical Science, Chongqing Medical University, Chongqing 400016, China.
Han YanDepartment of Pathogen Biology, College of Basic Medical Science, Chongqing Medical University, Chongqing 400016, China.
Honglin ChenDepartment of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Zhicheng YangDepartment of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Yiheng SunSchool of Savaid Stomatology, Hangzhou Medical College, Hangzhou, Zhejiang 311300, China.
Tianle GuDepartment of Pathogen Biology, College of Basic Medical Science, Chongqing Medical University, Chongqing 400016, China.
He LuDepartment of Pathogen Biology, College of Basic Medical Science, Chongqing Medical University, Chongqing 400016, China.
Hongyun ZhaoDepartment of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Zeng TuDepartment of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The invasive and metastatic potential of hepatocellular carcinoma (HCC) is tightly linked to lipid metabolic reprogramming. However, existing knowledge of the molecular regulatory network governing lipid metabolism in HCC remains incomplete. This study reveals for the first time that ADAR1 promotes HCC progression via direct binding to

Indexed as

8-ChloroadenosineADAR1Hepatocellular carcinomaLipid metabolismPPARγ

Identifiers

PMID42327978
PMCPMC13276139

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.