ArticleInternational journal of cardiology. Heart & vasculature2026
Cardiac sympathetic afferent denervation improves cardiac post-ischemic remodeling by maintaining autonomic tone.
Article in International journal of cardiology. Heart & vasculature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The autonomic imbalance can negatively affect left ventricular (LV) remodeling following a myocardial infarction (MI). Ganglionated plexi (GP) play a crucial role in autonomic nervous system imbalance. Cardiac sympathetic afferent denervation (CSAD) has been shown to have beneficial effects in addressing this imbalance. Objectives: This study aimed to evaluate the effects of the ablation of cardiac sympathetic sensory neurons on LV remodeling. Resiniferatoxin (RTX), a neurotoxic transient receptor potential vanilloid (TRPV1) antagonist, was used to achieve it. Methods and Results: A total of 31 beagle dogs were randomly assigned to three groups: MI group ( Conclusions: In conscious dogs with healed MI, CSAD led to a reduction in cardiac sympathetic tone and an improvement in ventricular remodeling. This suggests that targeting cardiac sympathetic sensory neurons through CSAD may have therapeutic benefits in managing LV remodeling after MI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.