ArticleFrontiers in pediatrics2026
Isolated prenatal foramen ovale closure or restriction presenting after birth: a distinct, under-recognized clinical condition.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The foramen ovale (FO) plays a central role in fetal circulation. Prenatal FO closure or restriction is well-characterized in fetuses and in neonates with congenital heart defects, but is rarely described as an isolated finding after birth. This study aimed to characterize the clinical presentation, echocardiographic features, management, and outcomes of neonates with isolated prenatal FO closure or restriction. Methods: We retrospectively analyzed 10 consecutive neonates admitted to our tertiary neonatal intensive care unit between September 2018 and August 2025 with FO closure or restriction diagnosed after birth. Results: The median gestational age was 39 + 1 weeks (range 36 + 4-41 + 1), and the median birth weight was 3,345 g (range 2,600-4,000 g). All the neonates presented within 9 h after birth, nine of them with central or differential cyanosis, seven with associated respiratory distress, and one with apnea. Echocardiography uniformly revealed persistent pulmonary hypertension of the newborn (PPHN) and significantly impaired left ventricular (LV) function with preserved right ventricular (RV) contractility. The interatrial septum was closed in six neonates and was restrictive in four. A prostaglandin infusion was administered to nine neonates. All the patients received inotropic support and pulmonary arterial hypertension (PAH) therapy. In survivors, normalization of LV function occurred in 1-4 days, followed by transition to a predominant left-to-right ductus arteriosus (DA) shunt in 1-8 days. One neonate died from refractory LV failure and pulmonary hemorrhage; one developed global developmental delay. Conclusions: Isolated prenatal FO closure or restriction represents a distinct and likely under-recognized condition, causing severe neonatal PPHN associated with significant LV failure. These echocardiographic findings, together with preserved RV function, should prompt careful evaluation of the interatrial septum. Early recognition and hemodynamic support can lead to full recovery in the majority of cases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.