Evidence map›Paper›PMID 42327851›Full record

ArticleGeoHealth2026

Residential Greenspace and Domestic Gardens, Genetic Predisposition, and Incident Glaucoma: A Prospective Cohort Study.

Xinyu Zhang, Changjing Han, Xiaojing Liu, Ting Lu, Zixuan Zhang, Xinyu Zhu, Yikeng Huang, Chenxin Li, Xun Xu, Yong Sun and 2 more

Abstract read
In one paragraph

Article in GeoHealth, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xinyu ZhangDepartment of Ophthalmology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai PR China.
Changjing HanDepartment of Ophthalmology The Second Affiliated Hospital of Xi'an Jiao Tong University Xi'an China.
Xiaojing LiuJiading Branch of Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai PR China.
Ting LuJiading Branch of Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai PR China.
Zixuan ZhangDepartment of Ophthalmology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai PR China.
Xinyu ZhuDepartment of Ophthalmology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai PR China.
Yikeng HuangDepartment of Ophthalmology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai PR China.
Chenxin LiDepartment of Ophthalmology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai PR China.
Xun XuDepartment of Ophthalmology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai PR China.
Yong SunJiading Branch of Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai PR China.
Shuzhi ZhaoDepartment of Ophthalmology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai PR China.ORCID https://orcid.org/0009-0000-1880-4208
Zhi ZhengDepartment of Ophthalmology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While greenness has been linked to enhanced physiological and psychological health, its association with glaucoma remains unexplored. This study aims to investigate the effect of residential greenspace and domestic gardens on incident glaucoma. 357, 920 participants from the UK Biobank were included. Land use coverage percentages of greenspace and domestic gardens within 300 and 1,000 m buffers of participants' residential locations were estimated using land use databases. Cox regression models were used to estimate the association between greenness exposures and incident glaucoma. Four-way decomposition models were used to explore potential mediators or moderators in the pathway. Gene-environment interaction effects were tested using multi-trait genetic polygenic risk score of glaucoma and Myocilin p.Gln368Ter genotype. During a median (IQR) follow-up of 13.5 (12.8, 14.1) years, 4, 046 glaucoma cases occurred. After full adjustment, the fourth quartile of greenspace was associated with 17.7% (HR = 0.823, 95%CI 0.723-0.937,

Indexed as

domestic gardengene‐environment interactionglaucomagreennessgreenspaceintraocular pressure

Identifiers

PMID42327851
PMCPMC13277392

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.