ArticleFrontiers in neurology
Brain cortex activity of patients with disorders of consciousness under familiar and unfamiliar voice of subject's own name: an fNIRS-based study.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Although auditory sensory stimulation has been widely used in clinical occupational therapy practice for DOC, there is significant heterogeneity in specific implementation protocols. However, none of these studies have focused specifically on exploring the familiar voice of subject's own name (FV SON) vs. unfamiliar voice of subject's own name (UFV SON) calling. Functional near-infrared spectroscopy (fNIRS) has shown great potential in the clinical assessment of DOC, as it features both high portability and relatively high spatial resolution. Objective: This study used fNIRS to investigate the real-time cortical activation elicited by auditory sensory stimulation through FV SON and UFV SON in patients with DOC, aiming to provide meaningful guidance for clinical occupational therapy and treatment evaluation. Methods: A total of 64 participants with DOC were recruited for this study. FNIRS was used to detected blood oxygen signals during FV SON and UFV SON in the subjects. Statistical analyses were performed for intra-group differences and the relationships between fNIRS metrics and the scores of the CRS- Results: Participants with DOC under UFV SON stimulation exhibited deactivation in the Left Dorsolateral Pre-frontal Cortex (DLPFC-L). However, compared with the rest state (RS), participants with DOC under FV SON stimulation did not show deactivation in the DLPFC-L. Compared with the UFV SON stimulation, the peak value of participants with DOC under FV SON stimulation was greater in the DLPFC-L. However, compared with the FV SON stimulation, the peak value of participants with DOC under UFV SON stimulation was greater for the TC-L. Compared with the UFV SON stimulation, the initial slope of participants with DOC under FV SON stimulation was greater for PreM & SMC-L. Under FV SON stimulation, the peak values of the DLPFC-L and TC-L were positively correlated with the CRS- Conclusion: In conclusion, DOC patients show distinct cortical activation patterns under familiar vs. unfamiliar SON calling stimulation. This study is helpful for guiding auditory stimulation strategies or personalized rehabilitation in DOC. These conclusions warrant further validation in future larger, multicenter studies, multimodal neuroimaging, studies, and intervention-based studies. [ChiCTR2300074202].
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