Evidence map›Paper›PMID 42327801›Full record

ArticleFrontiers in neurology

Evidence for exponential progression in advanced Parkinson's disease: retrospective analysis of a prospective cohort study.

Sophie Merve Yener, Catherine Ding, Ganga Ganesvaran, Jane E Alty, Benjamin G Clissold, Craig D McColl, Katrina A Reardon, Mark Schiff, Peter A Kempster

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sophie Merve YenerNeurosciences Department, Monash Medical Centre, Melbourne, VIC, Australia.
Catherine DingNeurosciences Department, Monash Medical Centre, Melbourne, VIC, Australia.
Ganga GanesvaranNeurosciences Department, Monash Medical Centre, Melbourne, VIC, Australia.
Jane E AltyNeurosciences Department, Monash Medical Centre, Melbourne, VIC, Australia.
Benjamin G ClissoldNeurosciences Department, Monash Medical Centre, Melbourne, VIC, Australia.
Craig D McCollNeurosciences Department, Monash Medical Centre, Melbourne, VIC, Australia.
Katrina A ReardonNeurosciences Department, Monash Medical Centre, Melbourne, VIC, Australia.
Mark SchiffNeurosciences Department, Monash Medical Centre, Melbourne, VIC, Australia.
Peter A KempsterNeurosciences Department, Monash Medical Centre, Melbourne, VIC, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: While prospective cohort research in Parkinson's disease (PD) suggests a linear increase in motor disability, there is some clinico-pathological evidence for exponential progression in the final disease stage. Methods: Thirty-four patients with PD composed a long-term cohort. Defined Results: Median age at death was 78.4. Mean disease duration was 14.5 years. Late Discussion: Progression of motor disability accelerates in advanced PD. It is possible that the entire disease course has an exponential character.

Indexed as

cognitive impairmentdisease progressionexponential modelmotor disabilityParkinson’s disease

Identifiers

PMID42327801
PMCPMC13278871

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.