ReviewFrontiers in neurology
Sudden death across brain and heart: cardio-cerebral ion channel dysfunction as a potential risk-modifying mechanism linking epilepsy and long QT syndrome.
Review in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Sudden unexpected death in epilepsy (SUDEP) and long QT syndrome (LQTS) are severe disorders causing sudden death in the neurological and cardiovascular systems, respectively, and have traditionally been viewed as distinct clinical entities. However, their overlapping clinical phenotypes and partially shared genetic backgrounds suggest that, in a subset of patients, overlapping molecular mechanisms may contribute to neurocardiac vulnerability. This review systematically elucidates and bridges the potential mechanistic intersections between these two conditions at the level of ion channel dysfunction. It focuses on key shared ion channel genes, such as
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