ReviewFrontiers in immunology2026
Comprehensive insights into the roles of eosinophils in the mucosal immunity of gastrointestinal tract: defenders, destructors, and modulators.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Gut-Skin Axis in Atopic Dermatitis and Inflammatory Bowel Disease: Mechanisms, Microbiota, and Therapeutic Implications.Journal of personalized medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eosinophils have long been recognized as terminal effector cells in type 2 immunity; however, emerging evidence positions them as central regulators of intestinal homeostasis, immune modulation, and tissue adaptation. This review provides a comprehensive overview of gastrointestinal eosinophils, integrating recent advances in their development, regulatory mechanisms, functional subsets, and pleiotropic roles across tissues. The developmental and homing pathways that guide eosinophils to the gut are first discussed, with an emphasis on niche-derived signals that control their survival and localization. The functional heterogeneity of intestinal eosinophils is then highlighted, revealing marked transcriptional and spatial diversification. The diverse functions of gut eosinophils are further summarized, including their contributions to pathogen defense, tissue repair, mutual regulation with the microbiota, anti-tumor, and interactions with immune cells. Finally, the cross-tissue orchestration of eosinophil behavior is examined, with a focus on the gut-immune axis. By synthesizing current knowledge, this review aims to present a holistic picture of gastrointestinal eosinophil biology and to inspire new perspectives for understanding and treating eosinophil-associated intestinal disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.