Evidence map›Paper›PMID 42327766›Full record

ArticleFrontiers in immunology2026

Comparative analysis of whole spine and sacroiliac joint magnetic resonance SPARCC scores in patients with SAPHO syndrome and ankylosing spondylitis.

Yi Shen, Xiaoli Gu, Jingchen Yang, Mi Zhou, Zhimin Lin, Rongsheng Wang, Jia Liu, Mengru Guo, Chen Li, Qi Zhu and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
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Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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11 authors.

Yi Shen *Department of Rheumatology, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Xiaoli Gu *The Research Institute for Joint Diseases, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China.
Jingchen Yang *School of nursing, Beijing University of Chinese Medicine, Beijing, China.
Mi ZhouDepartment of Rheumatology, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Zhimin LinDepartment of Rheumatology, Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, China.
Rongsheng WangDepartment of Rheumatology, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Jia LiuDepartment of Rheumatology, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Mengru GuoDepartment of Rheumatology, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Chen LiDepartment of Rheumatology, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Qi ZhuDepartment of Rheumatology, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Dongyi HeDepartment of Rheumatology, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ankylosing spondylitis (AS) and SAPHO syndrome both involve the spine and sacroiliac joints with bone marrow edema (BME) on MRI, which can lead to spinal structural damage. No previous study has compared BME characteristics between the two diseases. Methods: 42 SAPHO and 60 AS patients with spinal or sacroiliac involvement underwent whole-spine and sacroiliac MRI. SPARCC scores for each spinal segment and sacroiliac joints, vertebral unit involvement frequency, and BME range, intensity, depth were compared. Correlation between SPARCC scores of the whole spine and sacroiliac joints and clinical indicators were analyzed in the two groups of patients. Results: SPARCC scores for all spinal segments and sacroiliac joints in AS patients were significantly higher than those in SAPHO syndrome patients (P < 0.01). Defining bone marrow edema as SPARCC score > 0, the positive rate of vertebral units in spinal segments and sacroiliac joints was higher in AS than in SAPHO syndrome (P < 0.05). The incidence of BME in the cervical, thoracic, and sacroiliac joints was higher in AS than in SAPHO syndrome (P<0.001), with no significant difference in the incidence of lumbar spine BME (P > 0.05); the incidence of bilateral sacroiliac joint edema also showed no intergroup difference (P > 0.05). Further analysis of the score composition in SPARCC-positive cases revealed: the extent scores for each spinal segment in AS patients were higher than those in the SAPHO group ( Conclusions: SAPHO and AS show similar BME characteristics on MRI. SAPHO patients have a smaller extent of BME in spine and sacroiliac joints, whereas spinal BME may have a stronger correlation with their physical function. In SAPHO patients with axial involvement, the treatment experience of SPA may have certain reference value.

Indexed as

Acquired Hyperostosis SyndromeMagnetic Resonance ImagingSacroiliac JointSpineSpondylitis, AnkylosingAdultBone MarrowEdemaFemaleHumansMaleMiddle AgedSeverity of Illness Indexankylosing spondylitisbone marrow edema (BME)SAPHO syndromeSPARCC scorewhole spine MRI

Identifiers

PMID42327766
PMCPMC13275675

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