ArticleFrontiers in immunology2026
SLy1-deficiency results in functional impaired, exhausted and senescent NK cells.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: SLy1 is an emerging adapter protein, exclusively expressed in lymphocytes. In NK cells it serves as ribosomal stabilizer and plays an important role for their maturation, survival and functionality. SLy1-deficient (SLy1 Objective: This study aimed to analyze phenotypical and functional characteristics of SLy1- and p53-deficient NK cells and to understand which impairments depend on both proteins. Results: We established a SLy1 Conclusion: In brief, we demonstrated that SLy1 is indispensable for adequate numbers of viable, activatable NK cells with an intact cytolytic capacity, and that those phenotypic alterations are p53-mediated. Furthermore, the absence of SLy1 leads to senescence and exhaustion of NK cells in an p53-independant manner. These findings correlate with the recently shown association of human SLy1-mutations with specific types of common variable immunodeficiencies. We therefore strongly recommend testing for mutations in the gene locus, especially in patients with unclear immunodeficiencies.
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