Evidence map›Paper›PMID 42327747›Full record

ReviewFrontiers in immunology2026

Mechanisms and biomarkers of immune checkpoint inhibitor-associated myocarditis: from T cell imbalance to multicellular crosstalk.

Jiawang Huang, Xiuli Xu, Yucheng Jin, Liping Qiao, Heng Yu, Wenbo Gao, Caie Li

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiawang HuangThe Second Clinical Medical School, Lanzhou University, Lanzhou, China.
Xiuli XuThe Second Clinical Medical School, Lanzhou University, Lanzhou, China.
Yucheng JinThe Second Clinical Medical School, Lanzhou University, Lanzhou, China.
Liping QiaoThe Second Clinical Medical School, Lanzhou University, Lanzhou, China.
Heng YuDepartment of Cardiology, The Second Hospital of Lanzhou University, Lanzhou, China.
Wenbo GaoThe Second Clinical Medical School, Lanzhou University, Lanzhou, China.
Caie LiDepartment of Cardiology, The Second Hospital of Lanzhou University, Lanzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but can induce immune-related myocarditis (ICI-MC), a rare yet life-threatening toxicity. This review elucidates the cellular and molecular mechanisms underlying ICI-MC, integrating insights from T-cell dysregulation, innate immunity, and stromal interactions. Pathogenesis involves α-myosin-driven clonal expansion of cytotoxic CD8

Indexed as

Immune Checkpoint InhibitorsMyocarditisT-LymphocytesAnimalsBiomarkersCell CommunicationHumansMacrophagesBiomarkersImmune Checkpoint Inhibitorsbiomarkersimmune checkpoint inhibitor-associated myocarditismacrophage polarizationmulticellular crosstalkT cell dysregulation

Identifiers

PMID42327747
PMCPMC13275462

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.