Evidence map›Paper›PMID 42327736›Full record

ArticleFrontiers in immunology2026

Type-1 inflammatory imprinting and programmed responsiveness to CD40L enhance Siglec-1-dependent HIV-1 trans-infection by dendritic cells.

E Grace Bothwell, Allison E DePuyt, Colleen R Zaccard, Renee R Anderko, Peter E J Shoucair, Holly A Bilben, Tatiana M Garcia-Bates, Abigail D Gerberick, Simon C Watkins, Nicolas Sluis-Cremer and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

E Grace Bothwell *Department of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, PA, United States.
Allison E DePuyt *Department of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, PA, United States.
Colleen R ZaccardDepartment of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, PA, United States.
Renee R AnderkoDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Peter E J ShoucairDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Holly A BilbenDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Tatiana M Garcia-BatesDepartment of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, PA, United States.
Abigail D GerberickDepartment of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, PA, United States.
Simon C WatkinsDepartment of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Nicolas Sluis-CremerDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Charles R RinaldoDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Robbie B MailliardDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cells (DC) play a central role in host immunity as they carry environmental cues from sites of infection to the lymphatics, where they subsequently direct appropriate adaptive immune responses. Importantly, this process is exploited by pathogens such as HIV-1, which utilize DC to efficiently facilitate HIV-1

Indexed as

CD40 LigandDendritic CellsHIV-1HIV InfectionsSialic Acid Binding Ig-like Lectin 1CD4-Positive T-LymphocytesCells, CulturedHumansInflammationSignal TransductionCD40 LigandSialic Acid Binding Ig-like Lectin 1SIGLEC1 protein, humanCD40Ldendric cells (DCs)HIV-1 trans-infectionSiglec 1tunneling nanotubes (TNT)

Identifiers

PMID42327736
PMCPMC13275350

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.